About the Project
This project uses a nematode system to uncover the mechanisms controlling asymmetric cell division. It will involve the use of use state-of-the-art genome engineering techniques, microscopy and bioinformatics tools to follow molecules in living organisms and mapping genetic traits.
Techniques that will be undertaken during the project:
- Gene editing tools to generated mutant nematodes (e.g., CRISPR/Cas9)
- Generation of transgenic nematodes (e.g., tagging of specific proteins with fluorescent markers)
- Microscopy (e.g., time lapse videos, confocal microscopy)
- Bioinformatics (e.g., writing scripts in Unix, R and Python)
- Statistics (R, Python)
Winter, E.S., Schwarz, A., Fabig, G., Feldman, J.L., Pires-daSilva, A., Muller-Reichert, T., Sadler, P.L., and Shakes, D.C. (2017). Cytoskeletal variations in an asymmetric cell division support diversity in nematode sperm size and sex ratios. Development 144, 3253-3263.
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