This project aims to determine the molecular structure of the interface between novel peptide self-assemblies and cell membranes through x-ray diffraction and molecular simulation. This project will generate knowledge to enable atomic scale engineering of peptide nanomaterials and exploitation of these materials to modulate cell responses. Expected outcomes include designed peptide nanostructures with specific chemical and physical cues to promote sustainable growth of desired cells whilst inhibiting undesirable responses. These outcomes should provide benefits in terms of a practical toolkit for tailoring structure and function of peptide nanostructures and open up a new era in molecular design of smart biomaterials.
Background in biophysics and/or peptide chemistry required.