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Automation of Chemical Process Development

Project Description

The development of chemical processes for the synthesis and manufacturing of pharmaceuticals relies on a largely manual research and development approach with large elements of trial and error-based optimization. This method of development is sufficient for current batch manufacturing methodologies where relatively limited process understanding is required. However, the move to transition to intensified continuous processes which have the potential to miniaturize pharmaceutical manufacturing to benchtop scale facilities for many drugs, requires increased process understanding and data for successful design, operation and control.

This project aims to develop a complementary computational design and automated experimental approach to enable rapid intervention free development and optimization of process conditions for chemical processes. The data rich quantitative process designs developed using this methodology will be translated directly to actionable manufacturing processes using small scale intensive 3D-printed equipment.

The successful candidate will form part of a multidisciplinary research team working within the Ferguson Group and SSPC Pharmaceutical Research Centre, in the UCD O’Brien Science Centre, focussed on the development of novel technologies centred on the synthesis, purification and delivery of Pharmaceuticals.

Funding Notes

The student will work under the supervision of Dr Steven Ferguson and should have an honours B.ENG/M.Eng in Chemical, Biochemical, Process, Bioprocess Engineering or equivalent. Applications and enquiries should be directed to Dr. Steven Ferguson at the School of Chemical and Bioprocess Engineering, University College Dublin, Ireland (). The stipend for this position will be €18,500 + full EU or non- EU fees paid for 4 years.

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