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Bacteriophage-based approaches for controlling infections associated with haemodialysis catheters


   Faculty of Biology, Medicine and Health


About the Project

Healthcare-associated infections cause life-threatening harm to patients, incur major additional treatment costs and is high NHS priority. Patients with kidney disease are especially susceptible to harm associated with dialysis catheter use. These catheters, essential to the delivery of life-sustaining dialysis treatment (70-75% of incident and 30-40% of prevalent dialysis patients and higher in developing nations) are a major driver of bloodstream infection and increased mortality in patients receiving dialysis. Antibiotic locks, systemic and topical antibiotics are the mainstay of management of both empiric and definitive infections. In an era of global emergency of infections with drug-resistant organisms, non-pharmacological approach to managing catheter infections would be game-changing.

Bacteriophages have been proposed as an alternative to antibiotics. We propose to develop a panel of bacteriophages with activity against prevalent pathogens isolated from dialysis catheters in a renal dialysis facility. These will be tested singly and in various combinations using a laboratory model of haemodialysis catheters. The model will be developed and optimised as part of the project. The project will be multidisciplinary and seeks to address a serious clinical unmet need.  

Entry Requirements

Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (or equivalent) in a related area/subject. Candidates with previous laboratory experience are particularly encouraged to apply.

How To Apply

For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (https://www.bmh.manchester.ac.uk/study/research/apply/). Informal enquiries may be made directly to the primary supervisor. On the online application form select the appropriate subject title.

For international students, we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences.

Equality, Diversity and Inclusion

Equality, diversity and inclusion is fundamental to the success of The University of Manchester, and is at the heart of all of our activities. The full Equality, diversity and inclusion statement can be found on the website https://www.bmh.manchester.ac.uk/study/research/apply/equality-diversity-inclusion/”


Funding Notes

Applications are invited from self-funded students. This project has yet to be classified. Details of our different fee bands can be found on our website View Website

References

Whittard E, Redfern J, Xia G, Millard A, Ragupathy R, Malic S, Enright MC. (2021) Phenotypic and Genotypic Characterization of Novel Polyvalent Bacteriophages With Potent In Vitro Activity Against an International Collection of Genetically Diverse Staphylococcus aureus. Front Cell Infect Microbiol. 2021 Jul 6;11:698909. doi: 10.3389/fcimb.2021.698909. eCollection 2021.
PMID: 34295840
Wu HHL, Nixon AC, Dhaygude AP, Jayanti A, Mitra S (2021). Is home hemodialysis a practical option for older people? Hemodial Int. 2021 Oct;25(4):416-423. doi: 10.1111/hdi.12949. Epub 2021 Jun 16.PMID: 34133069
Saville CR, Metris A, Humphreys GJ, O'Neill C, Barrett P, Fernandez-Piquer J, McBain AJ (2021) Transitory Shifts in Skin Microbiota Composition and Reductions in Bacterial Load and Psoriasin following Ethanol Perturbation. mSphere. 2022 Jun 21:e0017122. doi: 10.1128/msphere.00171-22.
El-Chami C, Choudhury R, Mohammedsaeed W, McBain AJ, Kainulainen V, Lebeer S, Satokari R, O'Neill CA.(2022) Multiple Proteins of Lacticaseibacillus rhamnosus GG Are Involved in the Protection of Keratinocytes From the Toxic Effects of Staphylococcus aureus. Front Microbiol. 2022 May 11;13:875542. doi: 10.3389/fmicb.2022.875542. eCollection 2022.
Singh G, Byrne C, Thomason H, McBain AJ. (2022) Investigating the microbial and metalloprotease sequestration properties of superabsorbent wound dressings Sci Rep. 2022 Mar 19;12(1):4747. doi: 10.1038/s41598-022-08361-3. PMID: 35306513
Fox LJ, Kelly PP, Humphreys GJ, Waigh TA, Lu JR, McBain AJ. (2022) Assessing the risk of resistance to cationic biocides incorporating realism-based and biophysical approaches.
J Ind Microbiol Biotechnol. 2022 Jan 20;49(1):kuab074. doi: 10.1093/jimb/kuab074.
PMID: 34718634
Jayasena Kaluarachchi TD, Campbell PM, Wickremasinghe R, Ranasinghe S, Wickremasinghe R, Yasawardene S, De Silva H, Menike C, Jayarathne MCK, Jayathilake S, Dilhari A, McBain AJ, Weerasekera MM. (2022) Distinct microbiome profiles and biofilms in Leishmania donovani-driven cutaneous leishmaniasis wounds. Sci Rep. 2021 Nov 30;11(1):23181. doi: 10.1038/s41598-021-02388-8. PMID: 34848752
Campbell PM, Humphreys GJ, Summers AM, Konkel JE, Knight CG, Augustine T, McBain AJ.
(2020) Does the Microbiome Affect the Outcome of Renal Transplantation? Front Cell Infect Microbiol. Dec 23;10:558644. doi: 10.3389/fcimb.2020.558644. eCollection 2020.
PMID: 33425774

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