About the Project
In addition to the possible detrimental effects of phages on human health (eg spread of antibiotic resistance genes, increased bacterial virulence), they also hold hope as novel source of antibiotics. The potential of bacteriophages to be used a therapeutics against pathogens is becoming increasingly recognised as is the use of phages to remodel the microbiome.
Despite the importance of bacteriophages, most of what we know about bacteriophages is based on a relatively small number of bacterial-phage host systems. Approximately 60% of phages that have been sequenced have been isolated on just 12 different genera of bacteria. These genera tend to be representative of human pathogens eg Salmonella sp , Myobacterium sp Shigella sp . However, there is a dearth of knowledge on the diversity of phages that infect the commensal bacteria found in the human gut. Furthermore, there is virtually no model phage-host model systems for commensal gut bacteria.
To fully understand the role of phages it is necessary to develop phage-host systems so that hypotheses may be tested.
UK/EU applicants only.
Applicants are required to hold/or expect to obtain a UK Bachelor Degree 2:1 or better in a relevant subject.
The University of Leicester English language requirements apply where applicable: https://le.ac.uk/study/research-degrees/entry-reqs/eng-lang-reqs/ielts-65
How to apply:
To apply for the PhD please refer to the guidelines and use the application link at https://le.ac.uk/study/research-degrees/funded-opportunities/bbsrc-mibtp
Please also submit your MIBTP notification form at https://warwick.ac.uk/fac/cross_fac/mibtp/pgstudy/phd_opportunities/application/
Project / Funding Enquiries: [Email Address Removed]
Application enquiries to [Email Address Removed]
UK/EU fees and stipend at UKRI rates. For 2020 this will be £15,285 pa
Poyet, M.; Groussin, M.; Gibbons, S.M.; Avila-Pacheco, J.; Jiang, X.; Kearney, S.M.; Perrotta, A.R.; Berdy, B.; Zhao, S.; Lieberman, T.D.; et al. A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research. Nat. Med. 2019.
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