Imperial College London Featured PhD Programmes
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Bactofilins and the bacterial cytoskeleton

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

Newly developed light and electron microscopy methods are revolutionising our understanding of bacterial cells. Once thought to be simple, bacteria have now been recognised at highly organised cells using many elements previously only known from eukaryotes. One such element is the bacterial cytoskeleton. We study bactofilins, a novel class of cytoskeleton elements involved in cell shape maintenance, cell division, polarity determination, and antibiotic resistance (see Mol. Microbiol. 2011; 80:1031-1051). The project comprises the structural and biochemical characterisation of bactofilins, the study of the numerous proteins binding to bactofilin as well as the cellular phenomena controlled by bactofilins. Depending on the interest and background of the student the project can be modified and can be more of a molecular biology project involving genetic (cloning, construction of deletions, etc.) or biochemical techniques (protein purification, protein-protein interactions, etc.) or more of a structural project involving various microscopic techniques (super resolution microscopy of the cytoskeleton, localisation studies, electron microscopy, etc.). Moreover, these aspects are not mutually exclusive.

Science Graduate School

As a PhD student in one of the science departments at the University of Sheffield, you’ll be part of the Science Graduate School – a community of postgraduate researchers working across biology, chemistry, physics, mathematics and psychology. You’ll get access to training opportunities designed to support your career development by helping you gain professional skills that are essential in all areas of science. You’ll be able to learn how to recognise good research and research behaviour, improve your communication abilities and experience technologies that are used in academia, industry and many related careers. Visit to learn more.

Funding Notes

Entry requirements
First class or upper second 2(i) in a relevant subject. To formally apply for a PhD position, you must complete the University's application form using the following link: View Website

*All applicants should ensure that both references are uploaded onto their application as a decision will be unable to be made without this information*.

How good is research at University of Sheffield in Biological Sciences?

FTE Category A staff submitted: 44.90

Research output data provided by the Research Excellence Framework (REF)

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