Oxford Brookes University
Faculty of Health and Life Sciences,
Department of Biological and Medical Sciences
3.5 year, full-time PhD iCASE studentship
Eligibility: Home UK/EU applicants who must be permanently resident in the UK/EU
Closing date: 20 March 2020
Start date: September 2020
Bursary p.a.: Bursary equivalent to UKRI national minimum stipend plus fees (2019/20 bursary rate is £15,009)
University fees and bench fees at the Home/EU rate will be met by the industrial sponsor, Oxford Expression Technologies Ltd, for the 3.5 years of the Studentship.
Supervisors: Prof Linda King, Dr Victor Bolanos-Garcia and Dr Adam Chambers
Baculoviruses are insect-specific viruses that have a fascinating, two-phase replication cycle that in phase one results in the release of budded virus to spread the infection between cells whether in insect larvae or in cultured insect cells. In phase 2, virus particles remain in the nucleus where they become embedded in a proteinaceous matrix to form polyhedra. Polyhedra are released from nuclei following nuclear lysis or disintegration and serve to protect virus particles during horizontal transmission between larvae.
This project aims to (1) understand the mechanisms involved in baculovirus-induced nuclear lysis to release polyhedra-containing virus particles; (2) investigate the role of cellular microtubules and viral protein P10 in this process through molecular, structural biology and microscopy techniques; and (3) investigate the possibility that by disrupting microtubules, P10 could be developed as a novel anti-mitotic therapeutic in cancer cells. The project would ideally suit an outstanding graduate with a strong interest in the study of virus-host interactions and/or molecular mechanisms of cell division regulation. Training and experience will be provided in a range of modern bioscience techniques including cell culture, virology, molecular biology, structural biology and microscopy
We are seeking a motivated and talented student to join our multi-disciplinary team working in an excellent research environment in modern well-equipped laboratories, which is in collaboration with Oxford Expression Technologies Ltd (OET), a small biotech company conveniently located within Oxford Brookes Bioinnovation Hub.
For further information contact Prof Linda King: [email protected]
or Dr Victor Bolanos-Garcia: [email protected]