About the Project
Genetic depletion, RNAi-mediated silencing or small molecule inhibition of Axl triggers asymmetrical cell division leading to epithelial repair and ciliated cell regeneration. This discovery has implications for conditions associated with epithelial barrier dysfunction, basal cell hyperplasia and continued turnover of dying cells.
What we require now is to translate these findings into human lung disease. Using cardiothoracic lung resection material we will isolate basal stem cells and profile phosphatidylserine recognising receptors on their surface. The functional implications of signalling through these receptors will be determined by analysing basal cell proliferation, cell fate decisions and response to environmental conditions in health and disease.
The successful candidate will gain expertise in basal cell identification, culture and differentiation. The student will gain extensive experience of flow cytometry, tissue culture techniques, molecular biology with CyTOF and single cell sequencing where appropriate in the project.
Candidates must hold, or about to obtain, a minimum upper second class undergraduate degree (or equivalent) in a subject relevant to immunology and/or stem cells. Prior laboratory experience and/or an MSc in an appropriate subject area would be an advantage.
This 3-year full-time PhD is open to candidates able to provide evidence of self-arranged funding/ sponsorship and is due to commence from January 2017 onwards.
Any enquiries relating to the project and/or suitability should be directed to Prof Hussell ([Email Address Removed]). Applications are invited on an on-going basis but early expression of interest is encouraged.
Informal enquiries may be made directly to the primary supervisor.
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