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Bayesian multi-parameter evidence synthesis for biomarker driven HTA decision making

   Department of Health Sciences

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  Dr S Bujkiewicz  No more applications being accepted  Competition Funded PhD Project (Students Worldwide)

Leicester United Kingdom Health Informatics Medical Statistics Statistics

About the Project

Wellcome Trust Studentship 2022

Precision medicine research identifies subgroups of patients, for example defined by genetic biomarkers in oncology, to which targeted therapies can be delivered successfully. When genetic markers are used to identify groups of patients who can benefit from targeted therapies, they are investigated in clinical trials. Such trials are often of mixed designs, with multiple genetic markers, making it difficult to combine their results in meta-analysis, often required for evaluation of new therapies; for example by the National Institute for Health and Care Excellence (NICE). The project aims to develop statistical methodology for evaluation of therapies, targeted on patient populations defined by genetic biomarkers, allowing for optimal use of diverse data sources (surrogate endpoints and different study designs) for purpose of health technology assessment (HTA) decision-making. The project will explore potential use of methods to incorporate information on the interactions between multiple biomarkers and on polygenic risk scores. The work will be conducted using Bayesian evidence synthesis methods with application to decision modelling. Developed methods will be tested in a simulation study and applied to data on effectiveness of pharmacological cancer therapies. Work will be conducted in collaboration with pharmaceutical industry partner with a potential opportunity for visiting them in Switzerland.

Additional Information

  • Open to UK and International Students.
  • 4 year Competition Funded
  • Candidates applying to the 4-year PhD should hold or expect to hold an undergraduate degree or a Master's degree in a relevant subject or overseas equivalent
  • Start date September 2022
  • Closing date for applications 11:59pm 1 December 2021.

For full details of the PhD Studentship, application advice and link to the application system please refer to CVs submitted via the enquiry form below will not be accepted.

Funding Notes

• Postgraduate research fee waiver at standard College of Life Sciences UK rates for all four years of the PhD
• Wellcome Trust stipend for all four years of the PhD* Wellcome Trust stipend rates: PhD Year 1 £19,919; Year 2 £21,542; Year 3 £23,298; Year 4 £23,997.
• International students who are not from an identified LMIC are welcome to apply but may be required to pay the difference between home student fees and international student fees for the duration of their studies.
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