This project is to be funded under the BBSRC Doctoral Training Partnership. If you are interested in this project, please make direct contact with the Principal Supervisor to arrange to discuss the project further as soon as possible. You MUST also submit an online application form - full details on how to apply can be found on the BBSRC DTP website View Website
As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.
1] Integrated Catalysis Opens New Arylation Pathways via Regiodivergent Enzymatic C-H Activation. J. Latham, H. H. Sharif, J.-M. Henry, B. R. K. Menon, S. A. Shepherd, M. F. Greaney, J. Micklefield Nature Commun. 2016, 7, 11873 (http://dx.doi.org/10.1038/NCOMMS11873);
 RadH: AVersatile Halogenase for Integration into Synthetic Pathways. B Menon, E. Brandenburger, H. H. Sharif, U. Klemstein, S. A. Shepherd, M. F. Greaney, J. Micklefield Angew. Chem. Int. Ed. 2017 (http://dx.doi.org/10.1002/anie.201706342);
 An Engineered Tryptophan Synthetase Opens New Enzymatic Pathways to -Methyltryptophan and Derivatives. D. Francis, M. Winn, J. Latham, M. F. Greaney, J. Micklefield ChemBioChem 2017, 18, 382-386 (http://dx.doi.org/10.1002/cbic.201600471);
 Extending the biocatalytic scope of regiocomplementary flavin-dependent halogenase enzymes. S. A. Shepherd, C. Karthikeyan, J. Latham, A.-W. Struck, M. L. Thompson, B. Menon, C. Levy, D. Leys and J. Micklefield Chemical Science 2015, 6, 3454-3460 (http://dx.doi.org/10.1039/C5SC00913H);
 Development of Halogenase Enzymes for Use in Synthesis. J. Latham, E. Brandenburger, S. A. Shepherd, B. R. K. Menon and J.Micklefield Chem. Rev. 2018, 118, 232-269 (http://dx.doi.org/10.1021/acs.chemrev.7b00032).