This project is to be funded under the BBSRC Doctoral Training Partnership. If you are interested in this project, please make direct contact with the Principal Supervisor to arrange to discuss the project further as soon as possible. You MUST also submit an online application form - full details on how to apply can be found on the BBSRC DTP website View Website
As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.
 Assessing the Influence of Mutation on GTPase Transition States using X-ray, 19F NMR, and DFT Approaches. Jin Y, Molt RW Jr, Pellegrini E, Cliff MJ, Bowler MW, Richards NG, Blackburn GM, Waltho JP. Angew Chem Int Ed Engl. (2017) 56 9732-5.
 Myc Phosphorylation in the Basic Helix-Loop-Helix Inhibits Binding to Max and DNA via Destabilization of Transient alpha-Helical Structures. Macek P, Embrey KJ, Holdgate GA, Nissink JWM, Panova S, Cliff MJ, Waltho JP, Davies RA. J. Biol. Chem. (2018) 293 9301-9310.
 Van der Waals Contact between Nucleophile and Transferring Phosphorus Is Insufficient To Achieve Enzyme Transition-State Architecture. Johnson LA, Robertson AJ, Baxter NJ, Trevitt CR, Bisson C, Jin Y, Wood HP, Hounslow AM, Cliff MJ, Blackburn GM, Bowler MW, Waltho JP. ACS Catalysis (2018) 8 8140-8153.
 Equatorial active site compaction and electrostatic reorganization in catechol-O-methyltransferase. Czarnota S, Johannissen LO, Baxter NJ, Rummel F, Wilson A, Cliff MJ, Levy CW, Scrutton NS, Waltho JP, Hay S. ACS Catalysis (2019) 9 4394-4401.
 Mapping hidden residual structure within the Myc bHLH-LZ domain using chemical denaturant titration. Panova S, Cliff MJ, Macek P, Blackledge M, Ringkjøbing Jensen M, Nissink JWM, Embrey KJ, Davies R, Waltho JP. Structure (2019) 27 1-10.