About the Project
The PhD student based in Manchester Institute of Biotechnology will be co-supervised by Dr. Neil Dixon, and Profs David Leys, and Nick Turner, and will be focused on i) engineering MarR-type transcriptional factors to recognise a non-natural aromatic chemicals of environmental and industrial importance, ii) applying the engineered TFs to evolve novel enzymatic functionality and optimise bio-catalytic capability, iii) integrating these individual enzymes and TFs into biosynthetic pathways for whole-cell biotransformation, and iv) using synthetic biology tools and principles to engineer the developed pathway.
The student will be trained in broad aspects of biotechnology, microbial gene expression regulation, biocatalysis, directed evolution, microbial fermentation, molecular biology and bio-analytical methods such GC-MS. This project would suit individuals interested in future careers in biotechnology, biocatalysis and bioprocessing.
Applications are invited from UK/EU nationals only. Applicants must have obtained, or be about to obtain, at least an upper second class honours degree (or equivalent) in a relevant subject.
Contact for further Information
For more details contact Dr Neil Dixon ([Email Address Removed])
Fields S, Church GM, Raman S. Engineering an allosteric transcription factor to respond to new ligands. Nat
Methods. 2016 13(2):177-83.
 Leopoldo F. M. Machado, Neil Dixon Development and substrate specificity screening of an in vivo
biosensor for the detection of biomass derived aromatic chemical building blocks Chemical Communications
(2016), DOI: 10.1039/C6CC04559F
 Williams TC, Pretorius IS, Paulsen IT. Synthetic Evolution of Metabolic Productivity Using Biosensors Trends
Biotechnol. 2016 4(5):371-81.
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