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(BBSRC DTP) Exploring the developing microbiome in new-born babies


Project Description

The gut microbiome contains a large diverse community of microorganisms with our bacteria being best understood. These bacteria play crucial roles for our health such as aiding in the digestion of food, production of key vitamins and metabolites and programming out immune system. However, we are not born with this microbiome and the foundation of the microbiome is shaped during birth and thereafter by how the baby is fed. Evidence suggests that an altered intestinal microbiome may activate an uncontrolled pro-inflammatory response and numerous condition have been linked with a perturbed microbial/host dynamic. Much of the conditions to date have been studied in adults. Much less is known about the interaction of the developing microbiome with the host immune response and the consequences for the host. Necrotising Enterocolitis (NEC) is a condition, which is associated with a perturbed microbiome and aberrant immune responses to the microbiome. NEC is a devastating neonatal gastrointestinal inflammatory disease, which mainly affects low birth weight (LBW) and preterm infants. NEC affects 10-15% of preterm births < 32 weeks gestation and remains the leading cause of death from gastrointestinal disease in premature infants. This disease will be used as a model system with which to explore the make-up and establishment of the microbiome and the dynamic interaction of microbes with each other and the host immune function that can trigger tolerance or inflammation.

Sheena Cruickshank https://www.research.manchester.ac.uk/portal/sheena.cruickshank.html
Andrew McBain https://www.research.manchester.ac.uk/portal/andrew.mcbain.html
Chris Knight https://www.research.manchester.ac.uk/portal/chris.knight.html
Ajit Maheever https://mft.nhs.uk/saint-marys/consultants/dr-ajit-mahaveer/

Entry Requirements:
Applications are invited from UK/EU nationals only. Applicants must have obtained, or be about to obtain, at least an upper second class honours degree (or equivalent) in a relevant subject.

Funding Notes

This project is to be funded under the BBSRC Doctoral Training Partnership. If you are interested in this project, please make direct contact with the Principal Supervisor to arrange to discuss the project further as soon as possible. You MUST also submit an online application form - full details on how to apply can be found on the BBSRC DTP website View Website

As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.

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