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(BBSRC DTP) Functional genomics of cutaneous ageing


Faculty of Biology, Medicine and Health

About the Project

Sustained improvement in health care systems has increased life expectancy, resulting in a shift towards an ageing global population. Age-induced biological changes have a direct impact upon the structure and function of human skin, leading to a marked loss of function at advanced ages. This makes the skin of older individuals more susceptible to infections, erosions and, with a reduced capacity to heal1, the burden of declining skin function has been highlighted by the World Health Organization as an emerging global challenge2. Hence, we need to understand the processes which drive cutaneous ageing, and identify modifiable targets, with the long-term aim of translation into interventions which maintain and/or support skin health for as long as possible.

In this translational studentship, we will examine the impact of epigenetic regulation of gene expression, using ATAC-seq, Hi-C and RNA-seq, in cells derived from young and aged human subjects. The successful candidate will receive training in clinical study design and delivery of in vivo studies, in addition to gaining an understanding of geroscience, skin biology and functional genomics with the ultimate aim of discovering target genes suitable for clinical intervention to maintain skin health in ageing populations.


https://www.research.manchester.ac.uk/portal/en/researchers/rachel-watson(46b38916-7986-4054-801e-1a1b3bce08d2).html

https://www.research.manchester.ac.uk/portal/en/researchers/gisela-orozco(2bf29dce-2d02-46b0-9a85-148a505aa37a).html

Entry Requirements:
Applicants must have obtained, or be about to obtain, at least an upper second class honours degree (or equivalent) in a relevant subject.

UK applicants interested in this project should make direct contact with the Principal Supervisor to arrange to discuss the project further as soon as possible. International applicants (including EU nationals) must ensure they meet the academic eligibility criteria (including English Language) as outlined before contacting potential supervisors to express an interest in their project. Eligibility can be checked via the University Country Specific information page (https://www.manchester.ac.uk/study/international/country-specific-information/).
If your country is not listed you must contact the Doctoral Academy Admissions Team providing a detailed CV (to include academic qualifications – stating degree classification(s) and dates awarded) and relevant transcripts.

Following the review of your qualifications and with support from potential supervisor(s), you will be informed whether you can submit a formal online application.

To be considered for this project you MUST submit a formal online application form - full details on how to apply can be found on the BBSRC DTP website http://www.manchester.ac.uk/bbsrcdtpstudentships




Funding Notes

Funding will cover UK tuition fees/stipend only. The University of Manchester aims to support the most outstanding applicants from outside the UK. We are able to offer a limited number of scholarships that will enable full studentships to be awarded to international applicants. These full studentships will only be awarded to exceptional quality candidates, due to the competitive nature of this scheme.

Equality, diversity and inclusion is fundamental to the success of The University of Manchester, and is at the heart of all of our activities. The full Equality, diversity and inclusion statement can be found on the website View Website

References

1. Blume-Peytavi U, Kottner J, Sterry W, Hodin MW, Griffiths TW, Watson REB, Hay RJ, Griffiths CEM. Age-associated skin conditions and diseases: Current perspectives and future options. The Gerontologist 56(S2):S230-S242, 2016
2. https://www.who.int/ageing/events/world-report-2015-launch/en/

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