About the Project
To this end, the successful applicant will receive training in the latest technologies that will allow them to define in detail how distinct classes of visually responsive neurons within the SCN control specific aspects of physiology. Hence, we have recently pioneered the development of sophisticated experimental techniques to demonstrate that the SCN contains subsets of neurons that respond to quite different types of visual signal (brightness, colour, spatial patterns; ).
We have also established an array of new technologies that will allow specific populations of clock cells to be identified, monitored and manipulated in intact animals [3,4], while also measuring key physiological changes [3-5]. In combination, these approaches will provide unprecedented insight into how environmental light influences health and well-being with significant practical applications.
Applicants must have obtained, or be about to obtain, at least an upper second class honours degree (or equivalent) in a relevant subject.
UK applicants interested in this project should make direct contact with the Principal Supervisor to arrange to discuss the project further as soon as possible. International applicants (including EU nationals) must ensure they meet the academic eligibility criteria (including English Language) as outlined before contacting potential supervisors to express an interest in their project. Eligibility can be checked via the University Country Specific information page (https://www.manchester.ac.uk/study/international/country-specific-information/).
If your country is not listed you must contact the Doctoral Academy Admissions Team providing a detailed CV (to include academic qualifications – stating degree classification(s) and dates awarded) and relevant transcripts.
Following the review of your qualifications and with support from potential supervisor(s), you will be informed whether you can submit a formal online application.
To be considered for this project you MUST submit a formal online application form - full details on how to apply can be found on the BBSRC DTP website http://www.manchester.ac.uk/bbsrcdtpstudentships
Equality, diversity and inclusion is fundamental to the success of The University of Manchester, and is at the heart of all of our activities. The full Equality, diversity and inclusion statement can be found on the website View Website
 Walmsley L, Hanna L, Mouland J, Martial F, West A, Smedley AR, Bechtold DA, Webb AR, Lucas RJ, Brown TM. (2015).
Colour as a signal for entraining the mammalian circadian clock. PLoS Biol. 13:e1002127.
 Paul S, Hanna L, Harding C, Hayter EA, Walmsley L, Bechtold DA, Brown TM. (2020). Output from VIP cells of the mammalian central clock regulates daily physiological rhythms. Nat Commun. 11:1453.
 D'Agostino G, Lyons D, Cristiano C, Lettieri M, Olarte-Sanchez C, Burke LK, Greenwald-Yarnell M, Cansell C, Doslikova B, Georgescu T, Martinez de Morentin PB, Myers MG Jr, Rochford JJ, Heisler LK. (2018). Nucleus of the Solitary Tract Serotonin 5-HT2C Receptors Modulate Food Intake. Cell Metab. 28:619-630.e5
 West AC, Smith L, Ray DW, Loudon ASI, Brown TM, Bechtold DA. (2017). Misalignment with the external light environment drives metabolic and cardiac dysfunction. Nat Commun. 8: 417
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