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(BBSRC DTP) Metal handling systems in metal-reducing bacteria: Application to engineering high activity biometallic catalysts for clickable chemistries

Project Description

This project will contribute to a multidisciplinary research team focussed on the development of a new approach to making high value chemicals for a range of industries (including pharmaceuticals), in the vibrant and rapidly developing area of industrial biotechnology. Using naturally occurring bacteria, that have been manipulated to accumulate nano-scale clusters of powerful catalytic metals (metallic nanoparticles), alongside enzymes that can transform target chemicals, the team aims to produce novel ‘biometallic catalysts’ via simple ‘one-pot’ processes. The studentship will build on previous work and will focus on the characterisation and optimisation of metallic nanoparticle synthesis in bacteria capable of reducing and precipitating metals. This will include uncovering and characterising the metal handling systems in these metal-reducing bacteria; including proteins involved in metal-sensing, metal-acquisition, metal-trafficking and metal-detoxification. The student will join a multidisciplinary team interfacing microbiology, nanotechnology, chemistry and biotechnology and use state of the art techniques from biology and the physical sciences. This work aims to provide novel solutions that can turn waste metal streams into high value materials for a wide range of industries via simple "one-pot" processes that are currently not available.

Entry Requirements:
Applications are invited from UK/EU nationals only. Applicants must have obtained, or be about to obtain, at least an upper second class honours degree (or equivalent) in a relevant subject.

Funding Notes

This project is to be funded under the BBSRC Doctoral Training Programme. If you are interested in this project, please make direct contact with the Principal Supervisor to arrange to discuss the project further as soon as possible. You MUST also submit an online application form - full details on how to apply can be found on the BBSRC DTP website View Website

As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.

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