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(BBSRC DTP) Optimisation of heteromeric protein complex formation via co-ordinated mRNA localisation


Project Description

RNA granules play key roles in cells controlling many aspects of mRNA fate. For instance, in response to stress the relocalisation of mRNAs to mRNA processing bodies (P-bodies) and stress granules facilitates the degradation or storage of unwanted or valuable mRNAs, respectively. Recently the Ashe lab have found that functionally-related mRNAs can be localised to RNA granules that serve as hubs or factories for the co-ordinated translation of whole pathways or processes. One function of such translation factories is thought to be the co-translational folding and assembly of heteromeric protein complexes. This project aims to study the cotranslational assembly of example heteromeric complexes in yeast using both in vivo and in vitro approaches. The key question as to what governs whether particular mRNA translation factories favour productive protein complexes or non-specific protein aggregates will be addressed. These studies will establish a set of rules that can be then applied to the production of biotechnologically relevant heterologous protein complexes – assessing whether targeting heterologous mRNAs to protein factories increases productivity and yield of protein complexes.

https://www.bmh.manchester.ac.uk/research/domains/cellular-development-systems/protein-fate/rna-processing/
https://www.bmh.manchester.ac.uk/research/domains/cellular-development-systems/protein-fate/cellular-responses/
https://www.bmh.manchester.ac.uk/research/domains/cellular-development-systems/protein-fate/protein-sorting/

Entry Requirements:
Applications are invited from UK/EU nationals only. Applicants must have obtained, or be about to obtain, at least an upper second class honours degree (or equivalent) in a relevant subject.

Funding Notes

This project is to be funded under the BBSRC Doctoral Training Partnership. If you are interested in this project, please make direct contact with the Principal Supervisor to arrange to discuss the project further as soon as possible. You MUST also submit an online application form - full details on how to apply can be found on the BBSRC DTP website View Website

As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.

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