About the Project
Intracellular signalling pathways rely on defined protein-protein interactions occurring in an ordered fashion at precise loca-tions and times within the cell. Elucidation of such protein-protein interactions with high spatiotemporal resolution is there-fore key for properly understanding cellular signalling events and developing therapies to treat the plethora of diseases caused by cell signalling alterations.
In this project we aim at developing a series of chemical and genetic engineering tools to allow the precise mapping of pro-tein-protein interactions in intracellular systems. These tools will then, in the first instance, be applied to mapping DNA Dam-age Repair (DDR) pathways. The DDR plays a major role in preventing major diseases such as cancer, and to ageing.
Moreover, the developed platform can be applied to almost any other question in cell biology to increase our fundamental understanding of the underlying signalling pathways and their associated disease pathologies.
• https://personalpages.manchester.ac.uk/staff/igor.larrosa/research.html
• https://www.research.manchester.ac.uk/portal/christine.schmidt.html
• https://www.mbc.manchester.ac.uk/barrangroup/
Entry Requirements:
Applicants must have obtained, or be about to obtain, at least an upper second class honours degree (or equivalent) in a relevant subject.
UK applicants interested in this project should make direct contact with the Principal Supervisor to arrange to discuss the project further as soon as possible. International applicants (including EU nationals) must ensure they meet the academic eligibility criteria (including English Language) as outlined before contacting potential supervisors to express an interest in their project. Eligibility can be checked via the University Country Specific information page (https://www.manchester.ac.uk/study/international/country-specific-information/).
If your country is not listed you must contact the Doctoral Academy Admissions Team providing a detailed CV (to include academic qualifications – stating degree classification(s) and dates awarded) and relevant transcripts.
Following the review of your qualifications and with support from potential supervisor(s), you will be informed whether you can submit a formal online application.
To be considered for this project you MUST submit a formal online application form - full details on how to apply can be found on the BBSRC DTP website www.manchester.ac.uk/bbsrcdtpstudentships
Equality, diversity and inclusion is fundamental to the success of The University of Manchester, and is at the heart of all of our activities. The full Equality, diversity and inclusion statement can be found on the website https://www.bmh.manchester.ac.uk/study/research/apply/equality-diversity-inclusion/
References
Gang-Wei Wang, Matthew Wheatley, Marco Simonetti, Diego M. Cannas, Larrosa, I.* (2020). Cyclometalated Ruthenium Cata-lyst Enables Ortho-Selective C–H Alkylation with Secondary Alkyl Bromides. Chem., 6, 1459.
• IF 20, ranked 2nd for original research in Chemistry.
Simonetti, M., Cannas, D. M., Just-Baringo, X., Vitorica-Yrezabal, I., Larrosa, I.* (2018). A Cyclometalated Ruthenium-catalyst enables late stage functionalisation of pharmaceuticals. Nat. Chem., 724‒731.
• IF 22, ranked 1st for original research in Chemistry.
Simonetti, M., Kuniyil, R., Macgregor, S., Larrosa, I.* (2018). Benzoate Cyclometalation Enables Oxidative Addition of Haloarenes at a Ru(II) Center. J. Am. Chem. Soc. 140, 11836.
• IF 15, ranked 3rd for original research in Chemistry.
Da Costa, I.C., Conte, F., Beli, P., Galanty, Y., Jackson, S.P., Schmidt, C. K.* UFMylation promotes DNA repair by non-homologous end-joining. (2020) in preparation
Schmidt, C. K., Galanty, Y., Sczaniecka-Clift, M., Coates, J., Jhujh, S., Demir, M., Cornwell, M., Beli, P., and Jackson, S. P. (2015). Systematic E2 screening reveals a UBE2D–RNF138–CtIP axis promoting DNA repair. Nat. Cell Biol. 17, 1458–1470.
• IF 20, ranked 5th/187 in Cell Biology excluding reviews.
Beveridge R, Migas LG, Das RK, Pappu R V., Kriwacki RW, Barran PE*. Ion Mobility Mass Spectrometry Uncovers the Impact of the Patterning of Oppositely Charged Residues on the Conformational Distributions of Intrinsically Disordered Proteins. J Am Chem Soc. 2019;141(12):4908-4918. doi:10.1021/jacs.8b13483
• IF 15, ranked 3rd for original research in Chemistry.
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