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Click here to search FindAPhD.com for PhD studentship opportunities(BBSRC DTP) Regulation of the expression dynamics of the ergosterol pathway in Saccharomyces and Candida yeasts.
About the Project
The fungal ergosterol metabolic pathway is fundamental both as a target for antifungal compounds and a biotechnological vehicle for the production of many steroid molecules. Our recent work has shown that the mRNAs encoding enzymes for specific metabolic pathways such as glycolysis and aromatic amino acid biosynthesis are co-localised and translated at specific sites which we have termed ‘translation factories’. This arrangement provides the benefit of allowing co-ordinated post-transcriptional control of functionally related mRNAs. Recent preliminary work suggests that a similar scenario may exist for the ergosterol pathway. Therefore in this project we aim to expand our understanding of the scope and mechanism of ergosterol pathway mRNA localisation both in Saccharomyces and Candida yeast species. We will explore the impact of stress and antifungal treatments on mRNA localisation, and investigate changes in the composition of the translation factories under these conditions.
Relevant links
https://research.manchester.ac.uk/en/persons/mark.p.ashe
https://research.manchester.ac.uk/en/persons/chris.grant
Eligibility
Applicants must have obtained or be about to obtain a First or Upper Second class UK honours degree, or the equivalent qualifications gained outside the UK, in an appropriate area of science, engineering or technology.
Before you Apply
Applicants must make direct contact with preferred supervisors before applying. It is your responsibility to make arrangements to meet with potential supervisors, prior to submitting a formal online application.
How To Apply
To be considered for this project you MUST submit a formal online application form - full details on eligibility how to apply can be found on the BBSRC DTP website https://www.bmh.manchester.ac.uk/study/research/funded-programmes/bbsrc-dtp/
Your application form must be accompanied by a number of supporting documents by the advertised deadlines. Without all the required documents submitted at the time of application, your application will not be processed and we cannot accept responsibility for late or missed deadlines. Incomplete applications will not be considered. If you have any queries regarding making an application please contact our admissions team [Email Address Removed]
Equality, Diversity and Inclusion
Equality, diversity and inclusion is fundamental to the success of The University of Manchester, and is at the heart of all of our activities. The full Equality, diversity and inclusion statement can be found on the website https://www.bmh.manchester.ac.uk/study/research/apply/equality-diversity-inclusion/
Funding Notes
References
Paralogous translation factors target distinct mRNAs to differentially regulate tolerance to oxidative stress in yeast.Cunningham J, Sfakianos AP, Kritsiligkou P, Kershaw CJ, Whitmarsh AJ, Hubbard SJ, Ashe MP, Grant CM. 2023. Nucleic Acids Res. 51: 8820-8835.
Integrated multi-omics reveals common properties underlying stress granule and P-body formation. 2021. Kershaw CJ, Nelson MG, Lui J, Bates CP, Jennings MD, Hubbard SJ, Ashe MP, Grant CM. RNA Biol. 18: 655-673.
Core Fermentation (CoFe) granules focus coordinated glycolytic mRNA localization and translation to fuel glucose fermentation. 2021. Morales-Polanco F, Bates C, Lui J, Casson J, Solari CA, Pizzinga M, Forte G, Griffin C, Garner KEL, Burt HE, Dixon HL, Hubbard S, Portela P, Ashe MP. iScience. 24: 102069.
Farnesol inhibits translation to limit growth and filamentation in C. albicans and S. cerevisiae. Egbe NE, Dornelles TO, Paget CM, Castelli LM, Ashe MP. 2017. Microb Cell. 20174: 294-304.
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