About the Project
Slit proteins are ligands for Robo receptors. This signalling pathway is well-characterised in neural development, but less is known about the expression of receptor and ligand proteins during mammalian cardiac and kidney development. Therefore, examining the expression pattern of Slit3 in heart and kidney at several stages during development will be a key initial step in the investigations in this project. We also are well-placed to investigate Slit3 function during development, because we have two Slit3 mutant mouse lines that are ideal model systems for the evaluation of the requirements for Slit3 during gestation. Detailed characterisation of organ development in these mutant mouse models, and comparison to wild type controls, will form a substantial part of the project. Additionally, we will incorporate the use of bioinformatics methods to interrogate large datasets examining gene expression, human sequence variation, and protein-protein interaction (amongst others) to formulate a better understanding of the overlap between developmental pathways utilised in the formation of the heart and kidney. Combined, these approaches will provide insights into the requirements for Slit3 during development and the malformations that arise when Slit3 function is disrupted.
Applicants must have obtained, or be about to obtain, at least an upper second class honours degree (or equivalent) in a relevant subject.
UK applicants interested in this project should make direct contact with the Principal Supervisor to arrange to discuss the project further as soon as possible. International applicants (including EU nationals) must ensure they meet the academic eligibility criteria (including English Language) as outlined before contacting potential supervisors to express an interest in their project. Eligibility can be checked via the University Country Specific information page (https://www.manchester.ac.uk/study/international/country-specific-information/).
If your country is not listed you must contact the Doctoral Academy Admissions Team providing a detailed CV (to include academic qualifications – stating degree classification(s) and dates awarded) and relevant transcripts.
Following the review of your qualifications and with support from potential supervisor(s), you will be informed whether you can submit a formal online application.
To be considered for this project you MUST submit a formal online application form - full details on how to apply can be found on the BBSRC DTP website http://www.manchester.ac.uk/bbsrcdtpstudentships
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