University College London Featured PhD Programmes
University of Oxford Featured PhD Programmes
University of Edinburgh Featured PhD Programmes
University of Exeter Featured PhD Programmes
The Hong Kong Polytechnic University Featured PhD Programmes

(BBSRC DTP) Sharpening up protein NMR: ultra-high resolution experiments

Project Description

NMR is one of the most important techniques for gaining information on proteins in solution, but the ability to resolve individual NMR signals is a prerequisite for successful analysis. The new class of pure shift NMR experiments has been shown to greatly enhance resolution for small molecules in solution, and initial results on proteins are very promising. Here we are going to develop a range of such methods for the study of protein structure and dynamics. Pure shift methods1-3 rely on suppressing the multiplet structure caused by spin-spin interactions to improve resolution, and are particularly promising for the very important class of proteins that have dynamic, flexible functional segments with high local motion.4,5 This project will deliver a family of pure shift methods which will enable much more detailed study of such proteins.
The project will be supervised by a team of researchers from the School of Chemistry at the University of Manchester, world-leading experts in the development of NMR spectroscopy methods and their application to biomolecules. The University of Manchester has excellent facilities for this research, with over 15 high resolution NMR spectrometers ranging from 300 to 800 MHz. This interdisciplinary project spans a range of disciplines from physics to biology and will provide extensive training in a range of research methods, allowing the student to acquire a broad set of skills including practical NMR spectroscopy, spin physics, biotechnology, protein expression, and scientific programming.

Entry Requirements:
Applications are invited from UK/EU nationals only. Applicants must have obtained, or be about to obtain, at least an upper second class honours degree (or equivalent) in a relevant subject.

Funding Notes

This project is to be funded under the BBSRC Doctoral Training Partnership. If you are interested in this project, please make direct contact with the Principal Supervisor to arrange to discuss the project further as soon as possible. You MUST also submit an online application form - full details on how to apply can be found on the BBSRC DTP website View Website

As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.


1. L. Paudel, R. W. Adams, P. Kiraly, et al., Angew. Chem. Int. Ed., 2013, 52, 11616.
2. P. Kiraly, R. W. Adams, L. Paudel, et al., J. Biomol. NMR, 2015, 62, 43.
3. M. Foroozandeh, R. W. Adams, N. J. Meharry, et al., Angew. Chem. Int. Ed., 2014, 53, 6990.
4. E. Carmelo, D. Barilla, A. P. Golovanov, et al., J. Biol. Chem., 2005, 280, 28683.
5. A. P. Golovanov, G. M. Hautbergue, A. M. Tintaru, et al., RNA, 2006, 12, 1933.

Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here
* required field
Send a copy to me for my own records.

Your enquiry has been emailed successfully

FindAPhD. Copyright 2005-2019
All rights reserved.