About the Project
This project will address the fundamental unanswered question, how do cells respond to extracellular ATP to mediate inflammatory responses? and will investigate the molecular mechanisms underlying the response of macrophages to extracellular ATP mediated by P2X7R during inflammation. This project will provide, for the first time, a comprehensive overview of the signalling triggered by the danger signal eATP in macrophages.
We are looking for enthusiastic and motivated candidates with a strong interest in cell biology and the use of molecular approaches to study a biologically fundamental question. This project includes training in a wide array of interdisciplinary techniques ranging from mass spectrometry, microscopy to antibody-based techniques such as immunofluorescence, western blotting and flow cytometry as well as gene editing by CRSPR/Cas9. The candidate will use a combination of macrophage cell lines and primary monocytes/macrophages for this project. The candidate will benefit from a stimulating environment and the cutting-edge facilities at the faculty of Biology Medicine and Health and the world-leading Lydia Becker Institute of Immunology and Inflammation. As a PhD student you will be encouraged to present your research at internal meetings as well as attending international conferences. Please email us if you are interested and would like to know more about the project.
Applicants must have obtained, or be about to obtain, at least an upper second class honours degree (or equivalent) in a relevant subject.
UK applicants interested in this project should make direct contact with the Principal Supervisor to arrange to discuss the project further as soon as possible. International applicants (including EU nationals) must ensure they meet the academic eligibility criteria (including English Language) as outlined before contacting potential supervisors to express an interest in their project. Eligibility can be checked via the University Country Specific information page (https://www.manchester.ac.uk/study/international/country-specific-information/).
If your country is not listed you must contact the Doctoral Academy Admissions Team providing a detailed CV (to include academic qualifications – stating degree classification(s) and dates awarded) and relevant transcripts.
Following the review of your qualifications and with support from potential supervisor(s), you will be informed whether you can submit a formal online application.
To be considered for this project you MUST submit a formal online application form - full details on how to apply can be found on the BBSRC DTP website http://www.manchester.ac.uk/bbsrcdtpstudentships
Equality, diversity and inclusion is fundamental to the success of The University of Manchester, and is at the heart of all of our activities. The full Equality, diversity and inclusion statement can be found on the website View Website
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