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Understanding the secretory pathway in health and disease The secretory pathway is present in all eukaryotes and essential for life. Nearly one third of all proteins enter this pathway, including practically all membrane proteins and those proteins secreted from cells, including those that make up skin, bone and connective tissue, hormones, digestive enzymes, antibodies and many others. The Golgi apparatus lies at the heart of the secretory pathway where it functions as a hub for protein trafficking. Dysfunction of the Golgi is responsible for many diseases, contributes to complex pathologies such as cancer and neurodegeneration, and is part of the ageing process, highlighting the importance of this organelle for human health. The Golgi is also essential for the replication of intracellular viruses, including SARS-CoV2. Hence it is important we understand how the Golgi apparatus functions at the molecular level. The specificity of trafficking at the Golgi is dictated by the golgin proteins, but their importance in different cell types and tissues remains poorly understood. In this project, a combination of cell biology and in vivo analysis using the model organism C. elegans will be used to address these outstanding questions. The combined experiments will reveal the functional importance of golgins in the secretory pathway, and the role they play in tissue development and homeostasis. Combinatorial experiments will also reveal the extent to which these proteins may operate in a redundant manner, as has been proposed. The project will provide new insights into how the secretory pathway operates at the molecular level, which has important implications for our understanding of human health and disease.
https://www.research.manchester.ac.uk/portal/martin.p.lowe.html
https://www.research.manchester.ac.uk/portal/gino.poulin.html
https://research.manchester.ac.uk/en/persons/viki.allan
Eligibility
Applicants must have obtained or be about to obtain a First or Upper Second class UK honours degree, or the equivalent qualifications gained outside the UK, in an appropriate area of science, engineering or technology.
Before you Apply
Applicants must make direct contact with preferred supervisors before applying. It is your responsibility to make arrangements to meet with potential supervisors, prior to submitting a formal online application.
How To Apply
To be considered for this project you MUST submit a formal online application form - full details on eligibility how to apply can be found on the BBSRC DTP website https://www.bmh.manchester.ac.uk/study/research/funded-programmes/bbsrc-dtp/
Your application form must be accompanied by a number of supporting documents by the advertised deadlines. Without all the required documents submitted at the time of application, your application will not be processed and we cannot accept responsibility for late or missed deadlines. Incomplete applications will not be considered. If you have any queries regarding making an application please contact our admissions team [Email Address Removed]
Equality, Diversity and Inclusion
Equality, diversity and inclusion is fundamental to the success of The University of Manchester, and is at the heart of all of our activities. The full Equality, diversity and inclusion statement can be found on the website https://www.bmh.manchester.ac.uk/study/research/apply/equality-diversity-inclusion/
Funding Notes
References
Witkos and Lowe (2017). Recognition and tethering of transport vesicles at the Golgi apparatus. Curr. Op. Cell Biol. 47, 16-23.
Lowe (2019). The physiological functions of the golgin vesicle tethering proteins. Front. Cell Dev. Biol. 7, 94.
Yarwood et al (2020). Membrane trafficking in health and disease. Dis. Mod. Mech. 13: dmm043448.
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