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BBSRC DTP White Rose Studentship - Mechanistic dissection of cohesin DNA loading process

Project Description

The DNA, our genetic information carrier, is accurately duplicated into ‘sisters’ and equally transmitted to the two new-born daughter cells during cell proliferation. To ensure the precise sharing out of the duplicated genetic information, sister DNAs produced after DNA replication are held together until they are ready to move to opposites poles of the cell, just before the cell divides. This phenomenon is called sister chromatid cohesion. Sister chromatid cohesion is mediated by a special machine called cohesin. Precise regulation of cohesin’s association with DNA is fundamental for its actions. Defects in this regulation compromise cohesin’s function, which in humans would lead to cancer and inherited developmental disorders (such as Cornelia de Lange CdLS and Roberts syndromes). Although cohesin has been studied over twenty years, our knowledge of molecular details in its DNA association has progressed very little. In this study, we will investigate the molecular mechanism by which cohesin is recruited to DNA using comprehensive genetic, biochemical, and cell biology approaches. Insight into this fundamental process will help us understand how DNA segregation sometimes fails in cell division, as in cancer cells, or how our developmental programme goes wrong, which gives rise to cohesin-related diseases.

Funding Notes

4 year BBSRC studentship, under the BBSRC White Rose Mechanistic Biology DTP
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Requirements: At least a 2:1 honours degree in a relevant subject, or equivalent. The interdisciplinary nature of this programme means that we welcome applications from students with backgrounds in any biological, chemical, and/or physical science, or students with mathematical backgrounds who are interested in using their skills in addressing biological questions.

Studentships are available to UK and EU students who meet the UK residency requirements. Further information on eligibility: View Website.

How good is research at University of Sheffield in Biological Sciences?

FTE Category A staff submitted: 44.90

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