About the Project
This PhD studentship aims to improve understanding of this complexity by investigating how hypothalamic GPCRs may interact with each other and how their signal pathways may cross-talk. Using a multidisciplinary approach including molecular, computational and biophysical techniques, combined with state-of-the-art single-molecule imaging, this studentship aims to interrogate the signalling and trafficking of hypothalamic GPCRs to discover how they interact and how their signal pathways cross-talk. The student will learn a variety of techniques to examine GPCR function including cell culture, molecular biology (e.g. cloning), structural modelling, biophysical techniques (peptide interference), signalling assays (FRET, BRET, split-luciferase) and single-molecule (super-resolution) microscopy.
Research will be performed principally in the laboratory of Dr Caroline Gorvin within the Institute of Metabolism and Systems Research at the University of Birmingham. The appointee will also undertake some studies under the supervision of Professor Dmitry Veprintsev at the University of Nottingham, who specialises in structural and biophysical characterisation of GPCRs. The student will be expected to embrace being part of a world-class metabolic research institute within IMSR and an innovative interdisciplinary environment in the Centre of Membrane Proteins and Receptors (COMPARE).
Applicants should have a strong background in cell biology or pharmacology and an interest in membrane proteins, GPCRs and advanced imaging techniques. They should hold or realistically expect to obtain at least an Upper Second Class Honours Degree in biology or chemistry.
Stipend: RCUK standard rate
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