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BBSRC MIBTP: Understanding life after cell death


School of Biosciences

, Dr C M Bunce Sunday, January 10, 2021 Competition Funded PhD Project (Students Worldwide)

About the Project

Apoptosis, a major form of programmed cell death, is frequently activated in response to stress to remove damaged cells in multi-cellular organisms. It is therefore the guardian of health. However, it has long been a mystery how tissue recovers after damaged cells are removed. Work by us and others has revealed that, surprisingly, apoptotic cells can actively promote compensatory proliferation of their neighbouring cells to maintain tissue homeostasis, a process termed Apoptosis-induced Proliferation (AiP). Recent studies in several organisms including Drosophila and mammals have revealed that AiP plays critical roles in tissue recovery and regeneration and, in pathological conditions, uncontrolled AiP can lead to excessive tissue overgrowth. Yet there is not much known about regulation of AiP at the cellular and molecular level. This PhD project is designed to further dissect the molecular anatomy of AiP. By using Drosophila as a model organism, combined approaches including genetic epistasis, molecular biology, proteomics, immunohistochemistry, advanced microscopy and quantitative data analysis will be employed to systematically identify and characterise novel regulators of AiP. As AiP is evolutionary conserved, this project will make substantial contributions to our understanding of the cellular strategies and the genetic pathways used to maintain tissue homeostasis and promote tissue repair.

Funding Notes

This studentship is competition funded by the BBSRC MIBTP scheme: View Website
Deadline: January 10, 2021
Number of Studentships available: 50
Stipend: RCUK standard rate (plus travel allowance in Year 1 and a laptop).
The Midlands Integrative Biosciences Training Partnership 2020 (MIBTP2020) is a BBSRC-funded doctoral training partnership between the Universities of Warwick, Birmingham, Leicester, Aston and Harper Adams. It delivers innovative, world-class research training across the Life Sciences to boost the growing Bioeconomy across the UK.
You can find information about eligibility and funding details here: View Website


References

Amcheslavsky A., Wang S., Fogarty C., Lindblad J.L., Fan Y. & Bergmann A. (2018). Plasma membrane localization of apoptotic caspases for non-apoptotic functions. Dev Cell 45: 450-464.

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