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  BBSRC PhD Studentship Organic, medicinal Chemistry and chemical biology: improving gene therapy in T cells


   Wolfson Institute for Biomedical Research

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  Prof David Selwood  No more applications being accepted  Funded PhD Project (Students Worldwide)

About the Project

PhD in organic, medicinal Chemistry and chemical biology. We have developed chemical inhibitors that cause the degradation of part of the innate antiviral response. For gene therapy, it is sometimes advantageous to disable these responses to allow the viral vectors carrying therapeutic genes to achieve a high efficiency of transduction. Many details of this innate defence process are unclear in T-cells and this project seeks to use chemical biology techniques (computer-aided design, organic synthesis, proteomics) to address this knowledge gap.

This PhD studentship is part of the Biotechnology and Biological Sciences Research Council (BBSRC) Collaborative Training Partnership (CTP) in Advanced Bioscience of Viral Products (ABViP). The ABViP-CTP is a comprehensive, multidisciplinary training programme designed to deliver the next generation of bioscience leaders who will advance research on the underpinning bioscience of viral products for future gene therapies and vaccines. Led by Oxford Biomedica (OXB) and involving both UCL and the University of Oxford, CTP students will have access to a wide-ranging portfolio of training opportunities at the Partner sites including taught courses and case studies designed to complement the doctoral research. Students trained through the ABViP CTP will gain a holistic insight into the research and development activities required to develop the medicines of the future, with the ability to see the world of medicines development through both an academic and industrial lens. For more info rmation about the ABViP CTP, please click on the following link.

UK master’s degree, or a minimum of an upper second-class UK Bachelor’s degree, in a relevant discipline, or an overseas qualification of an equivalent standard. We particularly welcome applicants from disadvantaged backgrounds, or via an unconventional career path. If you’re unclear as to whether you are eligible, we would encourage you to apply regardless. You can also contact the project supervisor (see details below). To learn more about the policies in relation to diversity and inclusion at UCL, please click here for further information.

Informal enquiries should be addressed to David Selwood ([Email Address Removed])

The deadline for submission is Wednesday 10th July 2024 (12:00 midday GMT)

Interviews will be held on the 17th July 2024.

To apply for this PhD studentship, you must submit a formal application to the Research Degree: Division of Medicine RRDMDNSING01 course through UCL’s application portal by the above deadline. Please follow this link to make a formal application for the programme: https://www.ucl.ac.uk/prospective-students/graduate/research-degrees/medicine-mphil-phd.


Biological Sciences (4) Engineering (12)
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 About the Project