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BBSRC SWBio DTP studentship: Activation of the plant cell cycle by sugars; pathways involved in stimulation of CYCD expression by carbohydrates


Project Description

Plant growth on land, including the production of our food and non food crops, is ultimately the result of cell production and cell growth. These processes are energy demanding. The energy required for this is provided by the oxidation of sugars during respiration, and hence it is quite important that critical processes such as cell division are not started before sufficient sugars are available to execute the process effectively. This control is achieved by linking the levels and/ or activity of cell cycle regulators to the sugar levels. We uncovered that a regulator of cell cycle entry, CYCD2;1 is under control of sugars. If we understand the mechanism behind this, we might be able to improve the response of the cell cycle machinery to the sugars produced during photosynthesis, potentially stimulating plant growth. You will perform a genetic screen in Arabidopsis thaliana, a genetic model system, to identify candidate genes and pathways implicated in the stimulation of CYCD2;1 expression by sugars, The mutations will be identified by next generation sequencing of the entire genome. You will test the effect of these candidate regulators on cell cycle progression and plant growth under different growth conditions. This project will provide you with expertise in genome sequencing by next generation sequencing, bioinformatics, mutant screens, confocal imaging and molecular biology.

Eligibility

This studentship is available to UK and EU nationals who have established UK residency (EU nationals must have ordinarily lived in the UK throughout the three years preceding the start of the studentship). Please refer to the DTP eligibility webpage for more details: https://www.swbio.ac.uk/programme/eligibility/
Cardiff University will be able to award up to one fully funded four-year studentship for EU students who do not meet the residency requirements.

Entry requirements

Please refer to the DTP eligibility webpage for academic entry requirements: https://www.swbio.ac.uk/programme/eligibility/
If English is not your first language, you will need to achieve an IELTS score of 6.5 with 6.5 in all skills.

How to apply

Make your application to Cardiff University: https://www.cardiff.ac.uk/study/postgraduate/applying/how-to-apply
Please ensure that your application includes:
Two references. Neither of the referees should be part of the supervisory team.
Academic transcripts / degree certificate(s)
Personal statement. Please include supporting evidence for your Maths background.
Curriculum Vitae (CV)
English language certificates (where applicable)
Please refer to the DTP webpage for information about the selection process: https://www.swbio.ac.uk/programme/selection-process/

Applications must be submitted by midnight on Monday 2nd December 2019.

Funding Notes

This studentship will provide a stipend for 4 years in line with UK Research and Innovation (Research Council) rates (£15,009 in 2019/20), payment of university tuition fees, and a Research and Training and Support Grant (RTSG) to support the project.

How good is research at Cardiff University in Biological Sciences?

FTE Category A staff submitted: 54.70

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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