BBSRC White Rose DTP Studentship - A mechanistic understanding of phosphoinositide regulation during phagosome maturation

The capture and killing of microbes by immune cells is a key component of the innate immune system, and essential to protect the body from pathogens. We want to understand how captured microbes are processed and killed within host cells, and how this is regulated. 

A key element of this is delivery of digestive enzymes, through fusion with lysosomes. This must happen rapidly after potential pathogens have been captured to stop them escaping and causing an infection, but how this is achieved is not known. We have discovered a key regulator of this pathway is through phosphoinositide lipid signalling. The aim of this project is therefore to now work how this is controlled.

If you join us, you will join a well-established and well-funded research group and use cutting-edge live-cell microscopy, genetic and biochemical approaches to understand how microbes are processed by phagocytic cells. We offer a highly supportive and inclusive environment, with an excellent track record of discovery and publication. 

Students with a general interest in cell biology, trafficking and host-pathogen interactions are very warmly invited to apply, or contact us as [Email Address Removed] for an informal chat.

The BBSRC WR DTP and the University of Sheffield are committed to recruiting future scientists regardless of age, ethnicity, gender, gender identity, disability, sexual orientation or career pathway to date. We understand that commitment and excellence can be shown in many ways and we have built our recruitment process to reflect this. We welcome applicants from all backgrounds, particularly those underrepresented in science, who have curiosity, creativity and a drive to learn new skills.

Note: Relocation costs for international students to the UK (visa, insurance, NHS fees, flights, etc) will be the responsibility of the student 

 Entry Requirements: Students with, or expecting to gain, at least an upper second class honours degree, or equivalent, are invited to apply. The interdisciplinary nature of this programme means that we welcome applications from students with backgrounds in any biological, chemical, and/or physical science, or students with mathematical backgrounds who are interested in using their skills in addressing biological questions. 

 Click to apply

Programme: PhD in Mechanistic Biology (4 years)

Start Date: 1st October 2023

Shortlisted candidates will be interviewed mid February 2023