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BBSRC White Rose DTP Studentship - A novel bacteriophage defence system to control antibiotic resistant Campylobacter jejuni, the most prevalent food-borne pathogen

  • Full or part time
    Prof D J Kelly
    Dr J Rafferty
  • Application Deadline
    Monday, January 06, 2020
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

Campylobacter jejuni is the most common cause of food-borne gastroenteritis in the western world. Human infections result from consumption of contaminated chicken and the incidence has increased in recent years, including the emergence of multi-drug resistant campylobacters. New interventions are needed to reduce the numbers of the bacteria in the food-chain. One attractive possibility is the use of specific bacterial viruses (Phages) to kill Campylobacter in the food-chain. We have discovered that C. jejuni deploys a totally new type of phage defence system to protect itself against phage attack. This project will seek to understand how this system works and how we might inhibit or disable it, to make phage interventions more effective and thus reduce the burden of campylobacteriosis. This interdisciplinary project will provide training in molecular microbiological techniques including mutant construction, gene expression analysis as well as protein biochemistry and structural biology techniques.

Funding Notes

- a tax-free stipend at the standard Research Council rate (~£15,009, to be confirmed for 2020) for 4 years
- tuition fees at the UK/EU rate for 4 years.
- research costs

At least a 2:1 honours degree in a relevant subject or equivalent. The interdisciplinary nature of this programme means that we welcome applications from students with backgrounds in any biological, chemical, and/or physical science, students with mathematical backgrounds who are interested in using their skills in addressing biological questions.

Studentships are available to UK and EU students who meet the UK residency requirements. Further information on eligibility: View Website.

How good is research at University of Sheffield in Biological Sciences?

FTE Category A staff submitted: 44.90

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