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BBSRC White Rose DTP Studentship - Dissecting molecular mechanisms of organisation of cell polarity through use of in vivo single particle tracking in a living animal.

  • Full or part time
    Prof D Strutt
    Dr A Cadby
  • Application Deadline
    Monday, January 06, 2020
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

The genetic control of tissue morphogenesis is at the foundation of developmental biology, namely how cells decide to grow into a pre-determined shape to form a tissue or organ. The Strutt lab is interested in the decision to grow into flat sheets of cells sharing a common polarity, termed planar polarity. The core and Fat-Dachsous pathways that control planar polarity have been studied extensively in the lab using the model organism Drosophila melanogaster. This work has given insights into the bulk protein behaviours, however single molecule dynamics have not been possible to measure due to technological limitations.
This project will use quantitative approaches to fluorescence microscopy in vivo: fluorescence correlation spectroscopy (fcs) and single particle tracking (spt) to determine single protein dynamics using the Drosophila pupal wing model of planar polarity establishment. This project aligns with current super-resolution microscopy and molecular genetics projects within the lab.
Applicants interested in an interdisciplinary project combining genetics, molecular biology, cell and developmental biology, biophysics, quantitative analysis, fluorescence microscopy and statistics are encouraged to apply.

Funding Notes

- a tax-free stipend at the standard Research Council rate (~£15,009, to be confirmed for 2020) for 4 years
- tuition fees at the UK/EU rate for 4 years.
- research costs

At least a 2:1 honours degree in a relevant subject or equivalent. The interdisciplinary nature of this programme means that we welcome applications from students with backgrounds in any biological, chemical, and/or physical science, students with mathematical backgrounds who are interested in using their skills in addressing biological questions.

Studentships are available to UK and EU students who meet the UK residency requirements. Further information on eligibility: View Website.

How good is research at University of Sheffield in Biological Sciences?

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