BBSRC White Rose DTP Studentship - Investigating functional conservation of Specialized ribosomes in eukaryotes

Ribosomes are the ancient cellular machines that perform protein synthesis. Although long considered uniform in both composition and function, recent findings have shown ribosomes to be far more heterogeneous than originally thought. Heterogeneity can give rise to specialized ribosomes and provide a novel means by which gene expression can be regulated, through the selective expression of a subset of mRNAs. You will investigate ribosome specialization in yeast and human pluripotent stem cells using a combination of state-of-the art mass spec, transcriptomic and functional approaches. The work underlying this project will help to understand an exciting and fundamental mechanism regulating gene expression.

The BBSRC WR DTP and the University of Sheffield are committed to recruiting future scientists regardless of age, ethnicity, gender, gender identity, disability, sexual orientation or career pathway to date. We understand that commitment and excellence can be shown in many ways and we have built our recruitment process to reflect this. We welcome applicants from all backgrounds, particularly those underrepresented in science, who have curiosity, creativity and a drive to learn new skills.

Note: Relocation costs for international students to the UK (visa, insurance, NHS fees, flights, etc) will be the responsibility of the student 

Entry Requirements: Students with, or expecting to gain, at least an upper second class honours degree, or equivalent, are invited to apply. The interdisciplinary nature of this programme means that we welcome applications from students with backgrounds in any biological, chemical, and/or physical science, or students with mathematical backgrounds who are interested in using their skills in addressing biological questions. 

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Programme: PhD in Mechanistic Biology (4 years)

Start Date: 1st October 2023

Shortlisted candidates will be interviewed mid February 2023