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BBSRC White Rose DTP Studentship - Regulatory potential of 3’UTR introns in stem cell differentiation

  • Full or part time
    Dr I Sudbery
    Dr I Barbaric
  • Application Deadline
    Monday, January 06, 2020
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

Gene regulation is at the heart of many biological processes, including the processes by which embryonic stem cells differentiate to become adult tissues. One way in which genes are regulated is by the stability of their mRNA. This project involves investigating a novel mechanism by which RNA stability may be regulated and how this might impact on differentiation of human stem cells.

The project will involve a mixture of bioinformatics and laboratory based experiments. Existing and newly generated big-data sets will be analyzed to identify splicing events which may affect transcript stability. The effects of these events will then be validated and further explored in cell culture.

The student will be offered a uniquely comprehensive training in computational biology, next-generation sequencing analysis and stem cell lab techniques.

Funding Notes

- a tax-free stipend at the standard Research Council rate (~£15,009, to be confirmed for 2020) for 4 years
- tuition fees at the UK/EU rate for 4 years.
- research costs

At least a 2:1 honours degree in a relevant subject or equivalent. The interdisciplinary nature of this programme means that we welcome applications from students with backgrounds in any biological, chemical, and/or physical science, students with mathematical backgrounds who are interested in using their skills in addressing biological questions.

Studentships are available to UK and EU students who meet the UK residency requirements. Further information on eligibility: View Website

How good is research at University of Sheffield in Biological Sciences?

FTE Category A staff submitted: 44.90

Research output data provided by the Research Excellence Framework (REF)

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