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BBSRC White Rose DTP Studentship - The Conformational Dynamics of Two-Way DNA Junctions: A common first step in aberrant DNA recognition?

Project Description

Applications are invited for a BBSRC funded White Rose Doctoral Training Centre Studentship to study the conformational dynamics of aberrant DNAs. Experimental data from single-molecule FRET, fluorescent lifetimes spectroscopy, and other biophysical techniques, will be combined with molecular dynamic simulations (with Kresten Lindorff-Larsen in Copenhagen) to produce the most detailed view of aberrant DNA conformational dynamics to date. This multidisciplinary approach will help us understand the first step in aberrant DNA detection.

The successful student will join a vibrant and world-leading research grouping within the Krebs Institute for Mechanistic Biology and Imagine: Imaging Life, developing skills in cutting-edge single-molecule and ultrafast spectroscopy, and molecular modelling, with opportunities for industrial engagement as the project progresses.

Funding Notes

- a tax-free stipend, standard Research Council rate (£15,009, to be confirmed for 2020) for 4 years
- tuition fees, UK/EU rate for 4 years.
- research costs

Applicants must have at least a 2:1 honours degree in a relevant subject, or equivalent. The interdisciplinary nature of this programme means that we welcome applications from students with backgrounds in any biological, chemical, and/or physical science, or students with mathematical backgrounds who are interested in using their skills in addressing biological questions.

Studentships are available to UK and EU students who meet the UK residency requirements. Further information on eligibility: View Website

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