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BBSRC White Rose DTP Studentship - What are the molecular events that cause wound-induced muscle contraction?

  • Full or part time
    Dr H Roehl
    Prof I A Hope
  • Application Deadline
    Monday, January 06, 2020
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

Many animals possess a remarkable ability to regenerate organs after extensive damage. It is hoped that by studying these species we may learn the mechanisms that enable regeneration. This project aims to understand how animals respond to wounding and uses zebrafish and C.elegans to unravel signalling interactions that occur immediately following tissue damage. We have found that calcium released by the skin upon wounding causes neighbouring muscles to contract and this contraction activates regeneration. How this calcium release causes contraction is unknown, but we have developed a model that involves reactive oxygen and activation of the ryanodine receptor.
This project will use live-imaging and time-lapse recordings to track early signalling events, combined with genetic and pharmacological manipulation of signalling pathways. The student will receive training in use of two powerful model organisms (zebrafish and C.elegans) as well as state-of-the-art imaging (spinning-disc and SPIM microscopy). They will be hosted in Sheffield (Roehl Lab, BMS) and in Leeds (Hope Lab, FBS) as part of a unique collaborative project.

Funding Notes

- a tax-free stipend at the standard Research Council rate (~£15,009, to be confirmed for 2020) for 4 years
- tuition fees at the UK/EU rate for 4 years.
- research costs

At least a 2:1 honours degree in a relevant subject or equivalent. The interdisciplinary nature of this programme means that we welcome applications from students with backgrounds in any biological, chemical, and/or physical science, students with mathematical backgrounds who are interested in using their skills in addressing biological questions.

Studentships are available to UK and EU students who meet the UK residency requirements. Further information on eligibility: View Website.

How good is research at University of Sheffield in Biological Sciences?

FTE Category A staff submitted: 44.90

Research output data provided by the Research Excellence Framework (REF)

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