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Behavioural and biomechanical analysis of socially induced changes in body and brain structure in desert locusts

Project Description

All animals can tailor their phenotype to the environmental conditions they experience during their lifetime. Such phenotypic plasticity typically entails coordinated changes in morphology, physiology and behaviour. TM & SRO use the Desert Locust Schistocerca gregaria as a model to analyse phenotypic plasticity that is induced by social experience. Locusts respond to crowding by radically transforming from a shy, lone-living solitarious phase to a gregarious phase. This capacity to modify body, brain and behaviour underpins the formation of dense migratory swarms [1] that can devastate crops and pastures on a continental scale. TM and SRO have set up world-leading facilities for generating and working with both phases under precisely controlled laboratory conditions. TM has a strong track record in analysing the kinematics and biomechanics of insect limb movements [2].

Lifestyle-specific adaptations of the two phases include differences in body posture and locomotion [3]. Solitarious locusts walk infrequently and with a creeping gait, keeping the body close to the ground – but occasionally can walk very quickly. Gregarious locusts routinely use a rapid, stilted gait to walk huge distances - particularly as wingless juveniles. These pronounced behavioural differences are paralleled by differences in the musculoskeletal machinery of the thorax. This machinery underpins both walking and flight, with several bi-functional muscles serving in both behaviours. Further anatomical correlates of the different life styles are evident in the locust head. Adult gregarious locusts have smaller heads but larger brains than age-matched solitarious locusts, and the relative proportions of different brain regions also differ markedly [4]. However, we now have evidence that solitarious locusts, which are much longer-lived, far surpass gregarious locusts in brain size later in life.

In this project you will use X-ray computed micro-tomography (‘micro-CT’), a novel bioimaging technique that reveals internal structure in intact animals with micrometre resolution, to carry out the first simultaneous 3D computer reconstructions of the skeleton, musculature and central nervous system of the locust head and thorax. You will then apply Finite Element Analysis (FEA), a highly advanced computer modelling technique, to predict mechanical forces in the reconstructed skeletal structures. This will enable you to address fundamental questions about the scope and limits of structural plasticity in relation to behavioural plasticity along two broad lines:
(1) How does thorax structure differ between phases? How do skeletal differences relate to differences in muscle size and/or attachment angle, and to differences in posture and walking behaviour (limb joint angles and range of movements)? Are there structural compromises arising from the dual requirement for walking and flying? Do differences between the phases reflect different lifestyle trade-offs between walking and flying?

(2) Are there differences in head anatomy that relate to dietary differences, such as bigger chewing muscles in gregarious locusts that in turn require stronger skeletal reinforcement? How does brain size and composition change over time in the two phases? To what extent is brain shape determined by head size and shape?
1. Burrows M, Rogers SM, Ott SR (2011) Epigenetic remodelling of brain, body and behaviour during phase change in locusts. Neural Syst Circuits 1:11.
2. Ache JM, Matheson T (2013) Passive joint forces are tuned to limb use in insects and drive movements without motor activity. Curr Biol 23: 1418–1426.
3. Blackburn LM, Ott SR, Matheson T, Burrows M, Rogers SM (2010) Motor neurone responses during a postural reflex in solitarious and gregarious desert locusts. J Insect Physiol 56:902–10.
4. Ott SR, Rogers SM (2010). Gregarious desert locusts have substantially larger brains with altered proportions compared with the solitarious phase. Proc Biol Sci 277:3087–96.

Techniques that will be undertaken during the project
• X-ray computed micro-tomography — advanced bio-imaging of brain, skeletal structure, musculature and muscle insertions.
• 3D image processing and analysis — surface reconstruction, volumetric analyses of brain size and muscle development.
• Behavioural analyses — video tracking and analysis of limb movements.
• Finite Element Analysis of stress forces in the 3D-reconstructed skeletal structures — applying advanced mathematical modelling techniques that originate in Engineering / Material Sciences to biological systems.

Available to UK/EU applicants only
Application information

Funding Notes

4 year funded BBSRC Midlands Innovative Biosciences Training Partnership Studentship (MIBTP)
The funding provides a stipend at RCUK rates and UK/EU tuition fees for 4 years

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