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Bio2Brain: Nose-to-Brain Delivery of Biopharmaceutics for the therapy of central nervous system diseases: a design-based approach for efficient drug delivery systems


School of Biological & Chemical Sciences

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Prof Marina Resmini No more applications being accepted Funded PhD Project (Students Worldwide)
London United Kingdom Organic Chemistry Materials Science Pharmaceutical Chemistry Synthetic Chemistry

About the Project

Applications are invited for a 36 month, full-time Early Stage Researcher (ESR) position to work in the Department of Chemistry at Queen Mary University of London, as part of the EC Horizon 2020 funded Marie Skłodowska-Curie Innovative Training Network ‘Bio2Brain: Nose-to-Brain Delivery of Biopharmaceutics for the therapy of central nervous system diseases: a design-based approach for efficient drug delivery systems’ (EC Grant Agreement no: 956977). The position is offered in conjunction with a PhD programme at Queen Mary, subject to satisfying the admission requirements. The expected start date is 1st October 2021.

The Bio2Brain network will create a research environment for the interdisciplinary and intersectoral training of 13 ESRs across Europe, supported by 11 academic teams, 5 key industrial stakeholders and an academic non-profit organisation. The project is targeting the efficient delivery of drugs to the central nervous system (CNS). The research and training programme covers the development of new advanced materials, formulations, and engineered proteins for the intranasal CNS delivery of active pharmaceuticals.

The project at Queen Mary will focus on the synthesis and characterisation of novel nanogels for intranasal drug delivery of both small drug molecules as well as biopharmaceuticals, such as monoclonal antibodies. The research will target the evaluation of how changes in formulation can impact morphology, behaviour at the membrane interface as well as drug uploading and delivery. The ESR will attend annual summer schools and international meetings organised by the Network, and will be expected to complete a total of three secondments each, based with Bio2Brain beneficiaries in other countries.

The ESR appointed will work under the supervision of Prof Marina Resmini in the Department of Chemistry, based on the Mile End Campus. Queen Mary is one of the UK's leading research-focused higher education institutions, a member of the elite Russell Group of UK universities, and ranked joint 9th in the UK in the 2014 Research Excellence Framework. The Chemistry submission, in particular, was ranked 7th in the UK for research outputs.

Eligibility Requirements

The ideal candidate must have a Chemistry-based degree with a strong knowledge of organic chemistry, while some expertise in polymer/material chemistry and nanomaterial synthesis and characterisation are highly desirable. Candidates with degrees in Pharmacy, Food technologies and Chemical Engineering are not eligible to apply for this post. The researchers will enrol on the Chemistry PhD programme and will be required to meet the minimum English language requirements.

Due to this project being funded under the EC H2020 Marie Skłodowska-Curie Actions (MSCA), strict eligibility requirements apply. Applicants can be of any nationality but must not have lived, worked or studied in the UK for more than 12 months out of the 3 years immediately before the recruitment date. Compulsory national service, short stays such as holidays, and time spent as part of a procedure for obtaining refugee status are not taken into account. To qualify as "Early Stage Researchers" applicants should be within the first 4 years (full-time equivalent research experience) of their research careers, counted from the date in which their degree was obtained and have not been awarded a doctoral degree. Please see the EC H2020 MSCA ITN guidance for more information.

Candidates must be able to demonstrate their eligibility to work in the UK in accordance with the Immigration, Asylum and Nationality Act 2006. Where required this may include entry clearance or continued leave to remain under the Points Based Immigration Scheme.

Please note that the Fellowships are eligible for either a Skilled Worker visa, sponsored by Queen Mary, or a Global Talent visa under the Endorsed Funders route. A successful application under these routes will allow the successful candidates to work in the United Kingdom.

Application Process

Interested candidates are strongly advised, prior to applying, to read carefully the job description, to contact Prof Marina Resmini at [Email Address Removed] and send a CV and cover letter to ensure they are eligible to apply. Formal applications must be submitted online through the Queen Mary website by the 4th April 2021.

At Queen Mary, we believe that a diversity of ideas helps us achieve the previously unthinkable. Throughout our history, we’ve fostered social justice and improved lives through academic excellence. And we continue to live and breathe this spirit today, not because it’s simply ‘the right thing to do’ but for what it helps us achieve and the intellectual brilliance it delivers. We continue to embrace diversity of thought and opinion in everything we do, in the belief that when views collide, disciplines interact, and perspectives intersect, truly original thought takes form.

Further Information

For further information about the School, please see: http://www.sbcs.qmul.ac.uk. For the Resmini Group, please see: http://resminilab.sbcs.qmul.ac.uk/.


Funding Notes

The post is is funded under the EC Horizon 2020 funded Marie Skłodowska-Curie Innovative Training Network ‘Bio2Brain: Nose-to-Brain Delivery of Biopharmaceutics for the therapy of central nervous system diseases: a design-based approach for efficient drug delivery systems’ (EC Grant Agreement no: 956977). Estimated salary is £36,802pa - £40,360pa (dependent on family circumstances) and will be subject to exchange rate review. The funding will also cover full tuition fees. Applicants can be of any nationality but must not have lived, worked or studied in the UK for more than 12 months out of the 3 years immediately before the recruitment date.
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