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Biochemical mechanism controlling bacterial evasion of human inflammasome

Project Description

Your body is constantly targeted by pathogens like Salmonella, a food-borne
pathogen. Immune cells recognize and protect your body against infections
using a detection platform called the inflammasome. Inflammasomes has
been studied mostly in mouse, despite major differences with the human
immune system. We recently identify that Salmonella specifically evades
detection by human immune cells. However, the exact mechanism for such
evasion remain elusive. This exciting Ph.D. project will aim to understand
how Salmonella evades detection by the human inflammasomes through
specific effectors.

This project provides an outstanding training opportunity that combine
immunology, bacteriology and biochemistry. Techniques include but are not
limited to genetic engineering of cells, microscopy, flow cytometry, protein
expression, cellular immunology techniques and biochemical
characterization of protein interactions.

The graduate skills training through lab meetings, seminars, conferences,
and outreach activities will help you develop a broad range of scientific and
transferable skill in a highly supportive environment. The project is suitable
for applicants with strong interest in immunology and microbiology ready to
tackle a challenging but rewarding project.

Funding Notes

This is a BBSRC White Rose DTP studentship fully funded for four years and covers: (i) a tax-free annual stipend at the standard Research Council rate (£15,009 estimated for 2020 entry), (ii) research costs, and (iii) tuition fees at the UK/EU rate.


Entry requirements: Students with, or expecting to gain, at least an upper second class honours degree, or equivalent, are invited to apply. The interdisciplinary nature of this research project means that we welcome applications from students with backgrounds in any biological, chemical, and/or physical science, or students with mathematical backgrounds who are interested in using their skills in addressing biological questions.

Related Subjects

How good is research at University of York in Biological Sciences?

FTE Category A staff submitted: 44.37

Research output data provided by the Research Excellence Framework (REF)

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