About the Project
Significant efforts are being made to develop efficient technologies for wound care. Of these, liposomal formulations show promise as topical drug delivery systems. They attempt to address the twin goals of reaching and acting on the infection and damaged wound tissue, as well as provide an optimal environment to aid cell growth and migration. The advantages include their similarity to cell membrane phospholipid domains (and thus ability to support cell repair), providing a moist molecular film to promote epithelialization, and ability to facilitate the targeted release of an anti-microbial via their direct contact with microorganism cell membranes.
In this project, novel topical liposomal nanocarriers capable of converging selectively and deeply into the infection site, and loaded with a biofilm disruptor, will be developed. By degrading the biofilm, the efficacy of antimicrobial drugs will be increased at the wound site.
This should efficiently debulk the bacterial load thus expediting the wound healing process. Techniques which will be involved in the project include development and preparation of liposomal nanocarriers, and evaluation in both in vitro and in vivo experimental models of biofilms and chronic wounds.
This multidisciplinary project sets out to optimise the 1st step of what will ultimately be a multi-step strategy to manage bacterial numbers in chronic wounds. Even without development of further steps, this step alone will contribute to improving current wound management strategies.
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