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Biofilms - From Structure-Function to Antimicrobial Discovery


   School of Biological Sciences

This project is no longer listed on FindAPhD.com and may not be available.

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  Dr A M Hemmings  No more applications being accepted  Self-Funded PhD Students Only

About the Project

Antibiotic resistance has emerged as a major threat to public health. The treatment of many clinically relevant pathogenic bacteria pathogen has become increasingly difficult due to their capacity to resist antibiotics. The most persistent and dangerous infections by several of these organisms are associated with an ability to form a complex 3D colony, known as a biofilm.

An exciting PhD research studentship is available in the group of Prof. Andrew Hemmings in the School of Biological Sciences UEA to study the structure-function relationships of protein complexes involved in biofilm exopolysaccharide synthesis, editing and translocation. This will form the basis for discovery of inhibitory compounds with potential for development as antimicrobials. To achieve this the successful candidate will receive training in modern methods of molecular and structural biology, including X-ray crystallography and cryoelectron microscopy. The research will make extensive use of our excellent local facilities including the UEA Centre for Structural and Molecular Biochemistry and external facilities such as the synchrotron at the Diamond Light Source.

Suitably qualified individuals will have a strong interest in antimicrobial resistance and will hold, or expect to hold, a minimum upper second class honours undergraduate or good Masters degree (or equivalent) from any of a range of disciplines including, but not restricted to chemistry, biochemistry, biological chemistry or microbiology.

 

This project may be available at an earlier start date, but should first be discussed with Professor Hemmings.


Funding Notes

This PhD project is offered on a self-funding basis. It is open to applicants with funding or those applying to funding sources. Details of tuition fees can be found at https://www.uea.ac.uk/about/university-information/finance-and-procurement/finance-information-for-students/tuition-fees
A bench fee is also payable on top of the tuition fee to cover specialist equipment or laboratory costs required for the research. Applicants should contact the primary supervisor for further information about the fee associated with the project.
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