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Bioinformatics: Single cell genomics of tissue regeneration

  • Full or part time
  • Application Deadline
    Sunday, September 15, 2019
  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

Project Description

The newly established ‘Single cell genomics of tissue regeneration’ lab at CRG Barcelona will focus on the development of cutting-edge single-cell genomic and bioinformatic tools to study the maintenance, regulation and development of adult stem cells in health and disease, with a focus on the hematopoietic system and myeloid leukemia.

In the past, we have used single-cell RNA-seq to challenge the text book model of hematopoiesis (https://www.nature.com/articles/ncb3493), and we have developed integrated spatial and single-cell genomic approaches to map the organization of the hematopoietic stem cell niche (under revision). In parallel, we have developed methods to investigate mRNA isoform heterogeneity at the single cell level (https://doi.org/10.15252/msb.20156198), to study the effects of cancer mutations on gene expression (https://www.biorxiv.org/content/10.1101/500108v1), and to make single-cell RNA-seq more scalable (https://doi.org/10.1534/g3.117.300257).

In the new lab, we will build on this work in order to:

• Integrate single-cell RNA-seq with lineage tracing, using naturally occurring mutations, and use these methods to investigate the developmental origin and maintenance of lymphoid immune cells.

• Further develop tools to identify cancer stem cells in leukemia by single-cell genomics, and thereby identify drug targets specific to leukemic stem cells.

• Use single cell genomics as a tool for the engineering of synthetic gene regulatory elements with high lineage specificity.

Whom would we like to hire?

If you like to work in an interdisciplinary manner and pioneer new technologies, the lab might be the right environment for you.

• The ideal candidate should be highly motivated and must have practical experience in bioinformatics, a good working knowledge of statistics and substantial research experience. Knowledge of R and/or python and knowledge of the Linux command line is required.

• Candidates should have a University Degree and a Master’s Degree in physics, mathematics, statistics, genetics, bioinformatics, computer science or related disciplines within the European Higher Education System (minimum 300 ECTS) or equivalent by September 2019.

• The candidate needs to be proficient in English.

We provide a highly stimulating environment with state-of-the-art infrastructure, and unique professional career development opportunities. The successful applicant will enrol in the very active CRG International PhD program, which includes science and practical courses, a wide range of complementary skills training, access to many courses, mentoring via a thesis committee, and active participation in the organization of seminars, symposia and retreats.

Application

Applications are accepted exclusively online. Please, click the "Visit Website" button to access our online application system.

The deadline for the receipt of complete applications (including reference letters) is September 15, 2019. Proposals must be written in English. CRG offers and promotes a diverse and inclusive environment and welcomes applicants regardless of age, disability, gender, nationality, race, religion or sexual orientation.

Candidates may contact for academic enquiries, as well as address scientific enquiries to

All personal data requested by CRG from applicants will be treated in accordance with the principles of the Data Protection Act (15/13 December 1999).

Funding Notes

Contract duration: 4-year PhD position.
Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales.

Extramural funding of the group includes grants from the European Commission and the Spanish government.

References

https://scholar.google.de/citations?hl=de&user=JFRp2zoAAAAJ

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