About the Project
With our industrial partners, this will contribute to the development of new biologic drugs used as targeted therapies for use in specific cohorts of patients in fields including infection, autoimmune/inflammatory disease and cancer.
The project will involve regular visits to Immunocore including a placement of at least 3 months to generate TCR sequence datasets and to better understand the developability needs of their soluble TCR platform. Immunocore will provide training and mentorship in the areas of TCR discovery, TCR structure , developability of TCRs as soluble therapeutic agents, molecular cloning, protein expression, library preparation and mutagenesis, screening for binding, BIAcore, and structural studies as and when appropriate for the project. This translational project is expected to result in at least 3 papers being published and it will contribute to software licensing encompassing ‘big data’ and data science. The project will provide training in the biology of TCRs, the nature of NGS sequence data, big-data databases and software development. It will provide for personal development and acquisition of translational skills beyond a purely academic setting. The training will not only be in individual techniques, but also in the development of a pipeline from basic science to translation.
 Maciocia, et al. (2017) Nature Med 23:1416-23 (doi:10.1038/nm.4444)
 Cole, et al. (2016) J Clin Invest 126:2191-204 (doi:10.1172/JCI85679)
 Abhinandan & Martin (2008) Mol Immun 45:3832-39 (doi:10.1016/j.molimm.2008.05.022);
 Abhinandan & Martin (2010) PEDS 23:689-97 (doi:10.1093/protein/gzq043)
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