About the Project
This project aims to develop and use biological models to understand the mechanisms by which FGFR1 oncoproteins drive cancer and identify rational therapies to treat patients with FGFR1-altered cancers.
The student would perform functional validation of a novel FGFR1 fusion gene using a range of molecular and cell biology techniques including cell culture, viral transfection/transduction, flow cytometry, western blotting, cell viability and proliferation assays, and drug treatment assays. This work will be extended to include analysis of a broader range of FGFR1 variants to identify signalling mechanisms and drug susceptibilities that are common and unique to different FGFR1 variant classes. In addition to the techniques described above, the candidate will use unbiased screening methods including phosphoproteomics and high-throughput drug screening.
All students at the Institute must fulfil the requirements for enrolment at UNSW to undertake their PhD with us as well as obtain a scholarship that will cover both your living expenses and tuition fees. Scholarship and entry requirements will be provided on request.
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