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  Biology of ageing: investigating the effect of novel compounds and genetic interventions on longevity and functionality


   School of Biological Sciences

   Applications accepted all year round  Self-Funded PhD Students Only

About the Project

One of the goals of ageing research is to identify compounds that can extend lifespan and/or improve physical and cognitive performance in old age. The research of the last 20 years revealed a high level of conservation of genetic pathways and biochemical processes that regulate lifespan in organisms as diverse as yeast, worms, flies and humans. The fruit fly Drosophila, in particular, emerged as a pre-eminent model system for studying changes that occur during both normal and pathological ageing (~75 per cent of the genes that cause disease in humans are also found in the fruit fly!). The advantages of Drosophila include their relatively low cost, ease of use and a range of powerful tools available for their genetic manipulation.

We recently identified several genetic interventions and compounds with likely pro-longevity effects. The aim of this project is to assess the effect of these interventions during healthy (and, in some instances, pathological) ageing. The initial behavioural studies will be followed by an array of molecular, biochemical, imaging, functional and computational analyses.

Entry Requirements: Candidates are expected to hold (or be about to obtain) a minimum upper second-class honours degree (or equivalent) in a related area /subject. Candidates with experience in molecular biology, biochemistry, computational modelling, electrophysiology or Drosophila genetics are particularly encouraged to apply.


Biological Sciences (4)

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