Bangor University Featured PhD Programmes
Ulster University Featured PhD Programmes
Sheffield Hallam University Featured PhD Programmes
Birkbeck, University of London Featured PhD Programmes
University of Hull Featured PhD Programmes

Biology of ageing: investigating the effect of novel compounds on longevity and functionality

  • Full or part time
  • Application Deadline
    Monday, February 10, 2020
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

One of the goals of ageing research is to identify compounds that can extend lifespan and/or improve physical and cognitive performance in old age. The research of the last 20 years revealed a high level of conservation of genetic pathways and biochemical processes that regulate lifespan in organisms as diverse as yeast, worms, flies and humans. The fruit fly Drosophila, in particular, emerged as a pre-eminent model system for studying changes that occur during both normal and pathological ageing (~75 per cent of the genes that cause disease in humans are also found in the fruit fly!). The advantages of Drosophila include their relatively low cost, ease of use and a range of powerful tools available for their genetic manipulation.

We recently identified several plant-based compounds with possible pro-longevity effects. The main aim of this project is to assess the effect of these compounds during healthy ageing and in various Drosophila models of human diseases. The initial behavioural studies will be followed by an array of molecular, imaging and functional analyses. Sufficiently promising compounds identified in flies will then be tested for their ability to delay, prevent or reverse symptoms of ageing in mice.

This PhD project will be supervised jointly by:
1. Dr Hrvoje Augustin, Department of Biological Sciences, Royal Holloway University of London
2. Prof Dominic Withers, Faculty of Medicine, Institute of Clinical Sciences, Imperial College London

Applicants are invited to contact supervisor(s) by email ahead of submitting their application. Further information about applying for a postgraduate course at Royal Holloway can be found here:
https://www.royalholloway.ac.uk/studying-here/applying/postgraduate/how-to-apply/

Applications should be submitted online:
https://admissions.royalholloway.ac.uk/#/HEapplicationForm////////1

Funding Notes

Shortlisted eligible studentship applicants, will be notified within two-three weeks of the application deadline. Formal studentship interviews will usually be held within three-four weeks of the application deadline.
The funding for the project will cover home/EU tuition fees and a yearly stipend.

How good is research at Royal Holloway, University of London in Biological Sciences?

FTE Category A staff submitted: 24.00

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here
* required field
Send a copy to me for my own records.

Your enquiry has been emailed successfully





FindAPhD. Copyright 2005-2020
All rights reserved.