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Biomarkers in cervical cancer (GCRF)


Project Description

Standard treatment for locally advanced cervical cancer is radical chemoradiation. Hypoxia within the primary tumour is associated with local failure and metastatic disease. Hypoxia modification may therefore both improve local control and reduce the incidence of lethal metastatic disease. The combination of carbogen and nicotinamide (CON) reduces tumour hypoxia in animal models and improves radiotherapy outcomes in bladder and head and neck cancer patients. A phase II study of CON in cervical cancer has demonstrated feasibility in this setting. However, there are no validated biomarkers to identify cervix cancer patients who benefit from hypoxia-modifying treatment.

We hypothesise that tumour necrosis and/or lymphocyte count can be used to identify those patients who will benefit from CON and equally the group that have no benefit. The long term objective of this project is to validate a simple biomarker to select patients who respond to hypoxia modification in a phase II clinical trial within low and middle income countries.

Supervision will be from world-leading experts in radiotherapy and radiobiology from the UK and Sri Lanka. The appointed student will have the opportunity to develop a mix of core skills and experience supported by researchers within the Radiotherapy Related Research group. It is ideal for developing skills in both clinical and translational research as an ideal springboard towards developing an academic
career.

Entry Requirements
Candidates are expected to hold (or be about to obtain) an Upper Second class Honours degree (or equivalent) in a related area / subject.

If you are interested in this project, please make direct contact with the Principal Supervisor to arrange to discuss the project further as soon as possible. You MUST also submit an online application form - choose PhD Cancer Sciences. Full details on how to apply can be found on the GCRF website https://www.manchester.ac.uk/study/postgraduate-research/golden/gcrf/

Funding Notes

The GCRF PhD studentship programme is a 4 year programme with integrated teaching certificate. There are up to 12 studentships available. Applicants can apply to one project which will start in either April or September 2020.

Funding for the programme will include tuition fees, an annual stipend at the minimum Research Councils UK rate (around £15,000 for 2019/20), a research training grant, training allowance and travel allowance.

As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.

Related Subjects

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