Biomechanical Investigation of Tendinopathy: A Multiscale Study

Overview:

This PhD project aims to address the prevalent issue of tendinopathies, which significantly impact the general population and pose substantial socio-economic challenges globally. By delving into the mechanobiological behaviors of tendons at various scales—from the macroscopic tissue level down to the molecular collagen structure—this research seeks to investigate the underlying mechanisms of tendinopathies and pave the way for innovative treatments.

The project's objectives include investigating the structural organisation and mechanobiological response of type I collagen in tendons under two conditions: 1) external mechanical loading; and 2) various pathological states. It also seeks to explore the interplay between collagen structure and its biomechanical properties across multiple scales, thereby enhancing our understanding of tendon health and disease.

Initially, the focus will be on the structural and mechanical characterisation of tendons, specifically rat tail, rat Achilles, and turkey leg tendons. This foundational work will inform subsequent biomechanical analyses (computational simulations), relevant not only to tendinopathies but also to a broader spectrum of collagen-based biological tissues.

Techniques involved in this project:

The research may employ a suite of techniques, including:

·      Computational analyses (image analysis, finite element modeling).

·      Advanced imaging modalities (SEM, confocal, and multi-photon microscopy, X-ray scattering).

·      Mechanical testing equipments (Instron, digital image correlation).

Requirements:

We are seeking candidates with a strong background in biomechanics, bioengineering, or a related field, who are eager to contribute to research in tendon mechanobiology. The ideal applicant will possess a blend of experimental and computational skills, with a keen interest in physical imaging and computational simulation. All applicants should have, or expect to have, a first-class undergraduate degree (or equivalent) in mechanical engineering, solid mechanics, materials engineering, biomedical engineering, applied physics, or other related disciplines. The candidate should be highly motivated and have good written and oral communication skills, a genuine interest in research, and a desire to publish their work. While previous experience, e.g., through a relevant undergraduate project, in computational mechanics, and advanced imaging modalities, with computer programming knowledge in MATLAB, Fortran, or Python, is desired, it is not essential. The project will require both individual and group work; therefore, effective operation in both environments is highly desired.

Funding notes:

Funding is available for UK or EU students who have settled or pre-settled status in the UK. Successful candidates will be offered a 3 or 3.5-year fully-funded PhD scholarship. The expected start date will be in September 2024. 

How to apply:

Interested candidates are invited to submit their CV, academic transcripts, and a brief statement detailing their research interests and how their knowledge applies to the proposed topic. Please send your application to k.zheng@hw.ac.uk, referring to the project title. Shortlisted candidates will be contacted for interviews.

Closing date: applications will be evaluated on a rolling basis until a suitable candidate is appointed.