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Biomechanics of Osteoarthritis in moderate and severe primary OA that is biomechanically induced


Department of Bioengineering

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Prof A Bull Applications accepted all year round

About the Project

Osteoarthritis (OA) is a complex disease of the joints which is influenced both by biology and biomechanics. The mechanisms of OA are not yet fully identified. Therefore, there is little explanation of how the disease starts and progresses, nor there is detailed understanding of the different types of the disease so that a treatment method to be designed. Some types of the disease have their mechanical origins much more firmly established than others, yet the extent to which variable mechanical loading contributes is still not completely elucidated. Knee osteoarthritis (KOA) is a complex and multi-factorial disease with divergent ‘phenotypes’ each with its specific aetiology. This PhD project is focused on the development of models of the mechanical osteoarthritis (OA) phenotype caused by tibial malalignment that is under-studied and for which there is a lack of early diagnostic technologies, including biomechanical markers.

The aim of this project is to develop an understanding of the pathogenesis of KOA caused by tibial malalignment by answering the following key questions:

 What is the biomechanical effect of tibial alignment on knee joint loading and the initiation and progression of KOA?
 Does mechanical knee-malalignment initiated OA have a phenotype-related pathological pathway which may lead to the identification of specific treatment and diagnostic options?

To answer these questions, we are looking for a PhD who wants to focus on biomechanical studies in the context osteoarthritis who also has a background in biomechanics, Biomedical engineering, or a related field.

Prof. Anthony Bull’s group comprises a well-established team of researchers who have the required skills to support this PhD. The team is also supported by a team of clinical and academic experts. Based on the skills available in the team we can support the PhD project in Osteoarthritis in different ways including :
Biomechanics
Motion capture analysis
Pre-clinical models
Molecular biomarkers

Please contact Monique Mclaughlin for further details [Email Address Removed]

Funding Notes

This PhD is funded by Woodroffe Benton Foundation with the Department of Bioengineering at the standard UKRI funding rate



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