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Biomolecule Encapsulation within Synthetic Metal-Organic Materials


Project Description

Applications are invited for a fully-funded postgraduate studentship at the interfaces of chemistry, materials science and biochemistry. The position is available in the Riddell group from September 2019.

The successful candidate will form part of an expanding research group and receive full training in inorganic synthesis and a variety characterisation techniques that will enable them to design, synthesise and evaluate the outcome of metal self-assembly reactions in the presence of biomolecules. The interdisciplinary nature of the project will require the successful candidate to use a wide variety of characterisation techniques including NMR spectroscopy (1D, 2D and multinuclear), mass spectrometry, HPLC analysis, X-ray crystallography and fluorescence spectroscopy and microscopy, during the course of their research.

Our overall objective is to evaluate how spatial confinement may alter the conformation and thus reactivity of encapsulated biomolecules. Results from this research will thus prove informative in understanding cellular processes, where biomolecules are typically found in highly crowded environments, and may aid in characterisation of complexes normally disordered in dilute conditions.

Applicants should have or expect a good 2:i honours degree (or an equivalent degree) in Chemistry and be interested in pursuing highly interdisciplinary research at the boundaries of inorganic chemistry, materials science and biochemistry. Potential applicants must have good laboratory and analytical skills. The successful candidate must also be highly motivated, capable of working independently and demonstrate good communication skills.

Contact for further Information:
Applicants should contact Dr Riddell by email () enclosing a covering letter, detailed CV and details of two referees. Potential applicants seeking more information are also encouraged to contact Dr Riddell with any informal enquiries.

Funding Notes

This is a 3.5 year funded studentship covering all fees and stipend (£14.777 in September 2018). Open to UK/EU applicants only.

The start date for this PhD prgramme will be September 2019.

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