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Biopharmaceutics tools for Long Acting Injectables

   Department of Life Sciences

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  Dr Nikoletta Fotaki  No more applications being accepted  Funded PhD Project (UK Students Only)

About the Project

The University of Bath is inviting applications for the following PhD project to commence as soon as possible (date to be agreed with the lead supervisor).

Supervisory Team:

Overview of the Research:

Currently the development of long acting injectables (LAIs) is of high interest for the pharmaceutical industry. An understanding of drug performance at the site of administration is central to formulation development. Accurate simulation of the conditions at the site of administration is essential in order to reveal the critical factors affecting drug solubilisation and dissolution/ release from the formulation. Biorelevant in vitro testing conditions is regularly used in formulation development for orally administered drug products to aid prediction of the in vivo performance.

The aim of the proposed study is to fill the gaps in our understanding of physiological factors affecting drug solubilisation and dissolution/ release of active ingredient from LAIs, and in particular how to replicate the critical in vivo features in in vitro testing. These gaps include effects of fluid properties and composition at the site of administration and understanding which are the dominant effects on drug solubility and dissolution/ release from LAIs. These studies will result in the development of biorelevant media in which the critical components of the in vivo fluids will be incorporated. Studies on finding appropriate surrogates for some physiological components (i.e. due to high costs, practicalities) to be used in these media will be included. This work will result in the development of biopharmaceutics tools needed to predict in vivo performance of LAIs.

Project keywords: Biopharmaceutics, Long Acting Injectables, Biorelevant media, prediction of in vivo performance.

Candidate Requirements:

Applicants should hold, or expect to receive, a First Class or good Upper Second Class Honours degree (or the equivalent) in a relevant subject, preferably in Pharmacy, Pharmaceutical Sciences, Chemistry or Engineering. A master’s level qualification would also be advantageous.

Non-UK applicants must meet our English language entry requirement.

Enquiries and Applications:

Informal enquiries are welcomed and should be directed to Dr Nikoletta Fotaki on email address [Email Address Removed].

NOTE: Applications may close earlier than the advertised deadline if a suitable candidate is found; therefore, we recommend that you contact Dr Nikoletta Fotaki prior to applying and submit your formal application as early as possible.

Formal applications should be made via the University of Bath’s online application form for a PhD in Pharmacy & Pharmacology.

More information about applying for a PhD at Bath may be found on our website.

Funding Eligibility:

To be eligible for funding, you must qualify as a Home student. The eligibility criteria for Home fee status are detailed and too complex to be summarised here in full; however, as a general guide, the following applicants will normally qualify subject to meeting residency requirements: UK nationals (living in the UK or EEA/Switzerland), Irish nationals (living in the UK or EEA/Switzerland), those with Indefinite Leave to Remain and EU nationals with pre-settled or settled status in the UK under the EU Settlement Scheme). This is not intended to be an exhaustive list. Additional information may be found on our fee status guidance webpage, on the GOV.UK website and on the UKCISA website.

Equality, Diversity and Inclusion:

We value a diverse research environment and aim to be an inclusive university, where difference is celebrated and respected. We welcome and encourage applications from under-represented groups.

If you have circumstances that you feel we should be aware of that have affected your educational attainment, then please feel free to tell us about it in your application form. The best way to do this is a short paragraph at the end of your personal statement.

Funding Notes

The successful candidate will receive a 3-year studentship funded by GlaxoSmithKline (USA). The studentship will include Home tuition fees, a stipend (at least £16,062 per annum, 2022/23 rate) and an allowance for consumables and travel. Eligibility criteria apply – see Funding Eligibility section above.
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